Results 41 to 50 of about 19,224 (263)
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Route-Over Forwarding Techniques in a 6LoWPAN
6LoWPAN plays a major role within the protocol stack for the future Internet of Things. Its fragmentation mechanism enables transport of IPv6 datagrams with the required minimum MTU of 1280 bytes over 802.15.4-based networks.
Andreas Weigel +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
On Advancements of the Forward-Forward Algorithm [PDF]
The Forward-Forward algorithm has evolved in machine learning research, tackling more complex tasks that mimic real-life applications. In the last years, it has been improved by several techniques to perform better than its original version, handling a challenging dataset like CIFAR10 without losing its flexibility and low memory usage.
Ortiz Torres, Mauricio +2 more
openaire +6 more sources
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Conception of a Malicious Node Detection System for Tactical Wireless Sensor Networks [PDF]
This article presents the motivation and outlines a concept for mechanisms supporting data packet routing and exchange in tactical wireless sensor networks.
Wiesław JABŁOŃSKI (wieslaw.jablonski@interia.pl) +1 more
doaj +1 more source
Modeling transportation routes of the pick-up system using location problem: a case study
In today’s increasingly globalizing world, the demand for the transport of more and more specific kinds of goods is constantly growing. Greater diversity of the objects of transport extends the range of consignees and consignors, which implies the ...
Stopka Ondrej +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Averaged vibration levels during courier parcel delivery service in small truck in Hungary [PDF]
In recent years there continues to be an increase in courier parcel delivery services due to the growing global online economy and express parcel shipments.
Böröcz Péter
doaj

