Results 71 to 80 of about 1,795,357 (312)

Mitochondrial Signaling: Forwards, Backwards, and In Between

open access: yesOxidative Medicine and Cellular Longevity, 2013
Mitochondria are semiautonomous organelles that are a defining characteristic of almost all eukaryotic cells. They are vital for energy production, but increasing evidence shows that they play important roles in a wide range of cellular signaling and ...
S. Whelan, B. Zuckerbraun
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Longitudinal changes in anthropometric, physiological, and physical qualities of international women's rugby league players.

open access: yesPLoS ONE
This is the first study to assess longitudinal changes in anthropometric, physiological, and physical qualities of international women's rugby league players. Thirteen forwards and 11 backs were tested three times over a 10-month period.
Sean Scantlebury   +19 more
doaj   +1 more source

Abstract Hidden Markov Models: a monadic account of quantitative information flow

open access: yes, 2019
Hidden Markov Models, HMM's, are mathematical models of Markov processes with state that is hidden, but from which information can leak. They are typically represented as 3-way joint-probability distributions.
McIver, Annabelle   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

‘Setting the Benchmark’ Part 3: Contextualising the Match Demands of Specialised Positions at the FIFA Women’s World Cup Australia and New Zealand 2023

open access: yesBiology of Sport
This study aimed to benchmark the match demands of specialised positions at the FIFA Women’s World Cup Australia and New Zealand 2023. With FIFA’s official approval, all sixty four games at the tournament were analysed using an optical tracking system ...
Paul S. Bradley
doaj   +1 more source

Effect of formation, ball in play and ball possession on peak demands in elite soccer

open access: yesBiology of Sport, 2020
This study examined the most demanding passages of match play (MDP) and the effects of playing formation, ball-in-play (BiP) time and ball possession on the 1-min peak (1-min peak ) demand in elite soccer.
Andrea Riboli   +3 more
doaj   +1 more source

Forwards and Backwards Words [PDF]

open access: yes, 2002
This article is mainly concerned with what I will call Forwards and Backwards words, in which the letter progress forwards through the alphabet to the middle of the word, then backwards.
Gooch, Rex
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Push-forwards for Witt groups of schemes

open access: yes, 2011
We define push-forwards for Witt groups of schemes along proper morphisms, using Grothendieck duality theory. This article is an application of results of the authors on tensor-triangulated closed categories to such structures on some derived categories ...
Calmès, Baptiste, Hornbostel, Jens
core   +1 more source

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