Results 51 to 60 of about 295,278 (291)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Distributions and wave front sets in the uniform non-archimedean setting

, 2018
We study some constructions on distributions in a uniform $p$-adic context, and also in large positive characteristic, using model theoretic methods. We introduce a class of distributions which we call distributions of ${\mathscr C}^{\mathrm{exp}}$-class
Cluckers, Raf, Halupczok, Immanuel, Loeser, François, Raibaut, Michel   +3 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A DTN routing scheme for quasi-deterministic networks with application to LEO satellites topology [PDF]

, 2012
We propose a novel DTN routing algorithm, called DQN, specifically designed for quasi-deterministic networks with an application to satellite constellations.
Baudoin, Cédric, Diana, Rémi, Dubois, Emmanuel, Franck, Laurent, Gelard, Patrick, Lochin, Emmanuel   +5 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Longitudinal changes in anthropometric, physiological, and physical qualities of international women's rugby league players.

PLoS ONE
This is the first study to assess longitudinal changes in anthropometric, physiological, and physical qualities of international women's rugby league players. Thirteen forwards and 11 backs were tested three times over a 10-month period.
Sean Scantlebury, Nessan Costello, Cameron Owen, Sarah Chantler, Carlos Ramirez, Santiago Zabaloy, Neil Collins, Hayden Allen, Gemma Phillips, Marina Alexander, Matthew Barlow, Emily Williams, Peter Mackreth, Stuart Barrow, Parag Parelkar, Anthony Clarke, Benjamin Samuels, Stephanie Roe, Cameron Blake, Ben Jones   +19 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

‘Setting the Benchmark’ Part 3: Contextualising the Match Demands of Specialised Positions at the FIFA Women’s World Cup Australia and New Zealand 2023

Biology of Sport
This study aimed to benchmark the match demands of specialised positions at the FIFA Women’s World Cup Australia and New Zealand 2023. With FIFA’s official approval, all sixty four games at the tournament were analysed using an optical tracking system ...
Paul S. Bradley
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source