Results 131 to 140 of about 29,895 (169)

Chemogenetic activation of an A2 nucleus of the solitary tract to lateral parabrachial nucleus noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in male and female mice. [PDF]

Neuropharmacology
Drinkuth CR, Dornellas APS, Guarino S, Navarro M, Thiele TE.   +4 more
europepmc   +1 more source

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles (Lasiopodomys brandtii): Behavioral and Transcriptomic Insights

Integrative Zoology, EarlyView.
Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li, Congcong Qiao, Xiujuan Li, Maolin Huang, Zhenlong Wang, Luye Shi   +5 more
wiley   +1 more source

Transcriptomic Analysis Reveals Novel Mechanisms Underlying Neutrophil Activation Induced by High Salt. [PDF]

Int J Mol Sci
Mazzitelli I, Bleichmar L, Rivelli F, Feijoo I, Adamczyk A, Cabrerizo G, Erra Díaz F, Geffner J.   +7 more
europepmc   +1 more source

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source

Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection. [PDF]

Nat Commun
Yue L, Liang Y, Zhong P, Fang L, Yun Z, Su Q, Li C, Xiang M, Zhang J, Wang J, Ge L, Wu C, Chen H, Qiu X, Bo X, Tan Y.   +15 more
europepmc   +1 more source

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Enhanced <i>FOS</i> expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure. [PDF]

Sci Adv
Yin P, Yang J, Jiang Y, Han L, Xiong T, Liu H, Fang Y, Ruan W, Wu J, Chen L, Tan L, Zuo Y, Wu X, Mao F, Huang R, Liu X, Bian XW.   +16 more
europepmc   +1 more source

A conceptual framework for revealing rare bacterial species in the gut microbiome through guided data transformation: Beyond enterotypes

Methods in Ecology and Evolution, EarlyView.
Abstract The gut microbiota is increasingly recognized as a rich source of biological data that offers critical information on host health, including information on pathological conditions such as cancer, diabetes and other metabolic disorders. Inferring host health from gut bacterial composition using statistical analytical methods remains a challenge.
David Martin, Pierre Houedry, Frederic Derbré, Valérie Monbet   +3 more
wiley   +1 more source

Aqueous Extract of <i>Fructus Choerospondiatis</i> Peel Suppresses Vascular Inflammation and Alleviates Atherosclerosis via AKT/c-FOS/IL-6 Axis. [PDF]

Nutrients
Wu A, Dong J, Liu J, Gong X, Li X, Zhou B, Wan M, Lv W, Qiu J, Zhao Y, Fang Y, Huang J, Tian XL.   +12 more
europepmc   +1 more source

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Allergy, EarlyView.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat, Duygu Yazici, Can Zeyneloglu, Huseyn Babayev, Sena Ardicli, Asuncion Garci‐Sanchez, Xiangting Bu, Anja Heider, Oliva Giannelli Viscardi, Lihong Chang, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Ismail Ogulur, Cezmi A. Akdis   +16 more
wiley   +1 more source