Results 131 to 140 of about 26,336 (149)

Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progression

The FEBS Journal, Volume 292, Issue 7, Page 1558-1572, April 2025.
Breast cancer is a complex disease significantly influenced by estrogen receptors (ERs) and the extracellular matrix (ECM), both of which are critical in shaping tumor behavior. ERα and ERβ modulate cancer progression and therapeutic response with their interactions intricately linked to ECM dynamics.
Sylvia Mangani, Zoi Piperigkou, Nikolaos E. Koletsis, Paraskevi Ioannou, Nikos K. Karamanos   +4 more
wiley   +1 more source

Molecular characterization of PANoptosis-related genes in chronic kidney disease. [PDF]

PLoS One
Zhang WT, Ge HW, Wei Y, Gao JL, Tian F, Zhou EC.   +5 more
europepmc   +1 more source

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

The FEBS Journal, Volume 292, Issue 8, Page 1991-2016, April 2025.
Microtubule associated protein 2c (MAP2c) interacts with the regulatory protein 14‐3‐3ζ in a phosphorylation‐dependent manner. In its unphosphorylated state, MAP2c binds 14‐3‐3ζ via its microtubule binding domain and its central region. However, upon phosphorylation by cAMP‐dependent protein kinase (PKA), 14‐3‐3ζ preferentially binds to the ...
Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek   +7 more
wiley   +1 more source

Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells. [PDF]

PLoS One
Li B, Edick AM, Fox MK, Doelman J, Burgos SA, Cant JP.   +5 more
europepmc   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF. [PDF]

Nucleic Acids Res
Ahn H, Yu J, Ryu K, Ryu J, Kim S, Park JY, Kim JK, Jung I, An H, Hong S, Kim E, Park K, Ahn M, Min S, Jung I, Lee D, Lee T, Byun Y, Song JJ, Kim J, Cho WK, Lee G, Kim S.   +22 more
europepmc   +1 more source

Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor

The FEBS Journal, EarlyView.
NrdR is a bacterial transcription factor that regulates the expression of all three types of ribonucleotide reductase, an essential enzyme for cell survival, in response to intracellular ATP and dATP levels. We have carried out a comprehensive biochemical, biophysical and structural study of the response of E. coli NrdR to ATP and dATP.
Inna Rozman Grinberg, Ornella Bimaï, Saher Shahid, Lena Philipp, Markel Martínez‐Carranza, Ipsita Banerjee, Daniel Lundin, Pål Stenmark, Britt‐Marie Sjöberg, Derek T. Logan   +9 more
wiley   +1 more source

CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia. [PDF]

Theranostics
Qin X, Zhou K, Dong L, Yang L, Li W, Chen Z, Shen C, Han L, Li Y, Chan AKN, Pokharel SP, Qing Y, Chen M, Wang K, Leung K, Sau L, Chen CW, Deng X, Su R, Chen J.   +19 more
europepmc   +1 more source

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors

The FEBS Journal, EarlyView.
Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic strategies essential. This study focuses on the role of histone deacetylases (HDACs) in liver fibrosis, particularly HDAC6.
Maria Teresa Borrello, Dusan Ruzic, Hannah Paish, Eleanor Graham, Amy L. Collins, Rebecca Scott, Sam Higginbotham, Branko Radovic, Glyn Nelson, David Bulmer, Lee A. Borthwick, Stuart M. Robinson, Jeremy French, John Moir, Steve A. White, Colin Wilson, Sanjay Pandanaboyana, John Hammond, Rohan Thakkar, Wasfi Alrawashdeh, Rodrigo Figueiredo, Milos Petkovic, Katarina Nikolic, Fiona Oakley, Derek A. Mann, Jelena Mann   +25 more
wiley   +1 more source

Differential Cellular Responses to Class I and II Sphingomyelinase D: Unraveling the Mechanisms of <i>Loxosceles</i> Venom-Induced Dermonecrosis and Potential Therapeutic Targets. [PDF]

Int J Mol Sci
Pinto BF, Lopes PH, Trufen CEM, Ching Ching AT, Junqueira de Azevedo ILM, Nishiyama-Jr MY, de Souza MM, Pohl PC, Tambourgi DV.   +8 more
europepmc   +1 more source