Results 41 to 50 of about 26,336 (149)
ChemBioChem, Volume 26, Issue 11, June 3, 2025.This study reports the total synthesis of α‐galacto‐oligosaccharides (α‐GOSs) 1‐6 with different galactose chain lengths was achieved by the boron‐mediated aglycon delivery , and their immune‐enhancing activities in macrophage J774.1 cells. The results indicate that α‐GOS 2 exhibits the highest promotion of macrophage phagocytosis and increasing ...
Jikun Meng +3 more
wiley +1 more source
ChemBioChem, EarlyView.Targeted genome mining identified thermostable enzymes (PETases) that hydrolyze the commonly used plastic polymer polyethylene terephthalate (PET). Thermostable enzymes are identified from thermophilic microbial sources. Experimental results reveal enzymatic activity on authentic PET films, highlighting potential for industrial application.
Zhenyu Hu +4 more
wiley +1 more source
ChemBioChem, Volume 26, Issue 11, June 3, 2025.An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl +7 more
wiley +1 more source
SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core
ChemBioChem, EarlyView.The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic +15 more
wiley +1 more source
ChemistryEurope, EarlyView.The peroxo‐di‐cerium(IV)‐di‐lithium‐containing 32‐tungsto‐4‐phosphate [(CeIV2O2)Li2(P2W16O59)2]16− (Ce2Li2P4W32) is synthesized and structurally characterized. This peroxo‐polyanion demonstrates remarkable stability in solution across a broad pH range.
Anusree Sundar +8 more
wiley +1 more source
Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function
Chemistry – A European Journal, EarlyView.Organocatalytic switches are small molecules that combine active site affinity and a nitrogen‐centered base for catalysis, effectively removing the rate‐determining step of the OGG1 biochemical cascade. Here, we identify a minimal structure and modulate the active nitrogen pKa, enabling the catalysis of ultrafast AP site incisions in a range of pH ...
Mario Kehler +28 more
wiley +1 more source
A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity.
Chemistry – A European Journal, Accepted Article.Ketol‐acid reductoisomerase (KARI) is a target for the development of new biocidal agents. This is based on its essential role in branched chain amino acid biosynthesis in plants and microorganisms, and its absence in animals. The lack of success in developing KARI inhibitors as biocides may be because the inhibitors assessed to date compete directly ...
Luke William Guddat +9 more
wiley +1 more source
Corn cob pyrolysis: A systematic literature review of methods and applications
The Canadian Journal of Chemical Engineering, EarlyView.Mapping the research landscape of corn cob pyrolysis. Abstractas The agricultural sector is experiencing a surge in waste generation due to population growth, creating an urgent need to convert byproducts into value‐added products. Maize (Zea mays L.), a leading global crop, produces significant byproducts, such as corn cob, which are often undervalued.
Vilmar Steffen +5 more
wiley +1 more source
ChemMedChem, EarlyView.Cocktail soaking using single‐crystal X‐ray diffraction allows high‐throughput crystallographic ligand screening against protein targets. However, protein microcrystals are not amenable to this approach. Herein, a workflow integrating cocktail soaking with automated microcrystal electron diffraction to allow rapid ligand screening, structure ...
Jieye Lin +3 more
wiley +1 more source