Results 131 to 140 of about 542,291 (213)

Molecular mechanism of HaiZao-YuHu decoction in breast cancer treatment via network pharmacology and molecular docking: Computational pharmacology. [PDF]

Medicine (Baltimore)
Huang S, Lv Q, Pan R, Ma Y.
europepmc   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

High-Frequency rTMS can Improve Depressive Symptoms by Promoting Mitochondrial Fusion. [PDF]

Actas Esp Psiquiatr
Song J, Wang Y, Li S, Yuan J, Zhang Z, Pan Y, Lu J, Zhang Y.   +7 more
europepmc   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents. [PDF]

Sci Rep
Marongiu R, Wang J, Unda SR, Barbera J, Velazquez L, Li R, Jimenez-Gonzalez M, Tower W, de Silva N, Retik R, Stanley SA, Kaplitt MG.   +11 more
europepmc   +1 more source

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Cytomegalovirus and Crohn's disease as competing causes of small bowel inflammation after double-lung transplantation. [PDF]

Eur Clin Respir J
Niklassen JH, Hvas CL, Schønning K, Moestrup KS, Helleberg M, Perch M, Bendstrup E.   +6 more
europepmc   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

PPARγ as a predictive biomarker for antidepressant response in major depressive disorder: Insights from TNIP1 transcriptional regulation. [PDF]

Brain Behav Immun Health
Lin YW, Hwang DY, Hung YY.
europepmc   +1 more source

The Effect of Diabetes on Outcomes of Non‐Surgical Periodontal Therapy: A Systematic Review With a Meta‐Analysis and Trial Sequential Analysis

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective The aim of this systematic review was to critically assess and synthesise the current scientific evidence of the potential impact of diabetes mellitus (DM) on treatment outcomes in periodontitis patients following NSPT, incorporating recent advancements in meta‐analytical techniques.
L. P. M. Weijdijk, T. M. J. A. Thomassen, N. C. de Keyzer, E. E. J. Mayer, C. Valkenburg, G. A. van der Weijden, D. E. Slot   +6 more
wiley   +1 more source