Results 141 to 150 of about 39,429 (167)

Using Stochastic Simulation‐Estimation and Automated Model Development to Assess Power and Accuracy for Covariate Identification

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT When study designs are evaluated using clinical trial simulations for their ability to identify covariate effects in population pharmacokinetic (PopPK) modeling, it is typically assumed that the true model will be known at the data analysis stage. In this study, this was compared with the more realistic assumption that the PopPK model needs to
Ya‐Han Hsu, Bárbara Costa, Nuno Vale, Thomas P. C. Dorlo, Mats O. Karlsson   +4 more
wiley   +1 more source

Application of Population‐Based Meta‐Heuristic Algorithms for Robust Initialization in Mechanistic Pharmacometric Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Mechanistic PK/PD models represent complex biological systems in which model parameters are in nonlinear, multidimensional parameter spaces and often require robust optimization informed by experimental data, making parameter estimation a critical yet challenging aspect of pharmacometric analysis.
Dongjin Lee, Chih‐Wei Lin
wiley   +1 more source

Mechanistic insights into Shenqi Dihuang decoction in the treatment of immunoglobulin a nephropathy. [PDF]

Front Pharmacol
Gao Y, Pang X, Li D, Chen X, Li D, Chen Z.   +5 more
europepmc   +1 more source

High-Sugar Consumption Induces Anxiety-Like Behavior via Activating the Glutamatergic Neurons in the Nucleus of the Solitary Tract in Mice. [PDF]

Biology (Basel)
Wang P, Tan Y, Fan Z, He S, Chen C, Sun Y, Hong W, Wang Z, Zhang K, Fang EF, Liu Y, Zhang Z.   +11 more
europepmc   +1 more source

Integrated bioinformatics and network search identify biomarkers and comorbid mechanisms of atrial fibrillation and ischemic stroke. [PDF]

Medicine (Baltimore)
Liu B, Zhou X, Cai H, Zhu X, Xu Y, Wu J, Huang S, Zhou L, Weng H, Luo D.   +9 more
europepmc   +1 more source

Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis. [PDF]

Signal Transduct Target Ther
Shao L, Yu Y, Huang H, Chen Y, Teng X, Shen H, Ding Y, Zhou Y, Wang T, Shen Z.   +9 more
europepmc   +1 more source

Oligosaccharide prebiotics in functional foods and therapeutics: innovations and challenges. [PDF]

3 Biotech
Sandra KS, Vithalkar MP, Beere V, Bharath HB, Satyanarayana B, Rafiq M, Nayak Y.   +6 more
europepmc   +1 more source

Editorial: Neurobiological basis of substance use disorders: new findings and perspectives. [PDF]

Front Neurosci
Favoretto CA, Loss CM, Vozella V, Cruz FC.   +3 more
europepmc   +1 more source

Ischemic Stroke Incidence and Severity and Poststroke Cognitive Decline and Incident Dementia.

JAMA Netw Open
Koton S, Gross AL, Aparicio HJ, Beiser AS, Briceño EM, Coresh J, Elkind MSV, Giordani BJ, Gottesman RF, Hayward RA, Howard VJ, Johansen MC, Lazar RM, Springer MV, Stanton RJ, Sussman J, Wang H, Whitney RT, Ye W, Levine DA.   +19 more
europepmc   +1 more source

The experience of reorganizing the feldsher-obstetrical station (FOS) in the village of Koroviia, Hlyboka district into an outpatient clinic of general practice - of family medicine

2022
В статье приводятся социально-экономические, организационные и медицинские аспекты перестройки фельдшерско-акушерского пункта села Коровия Глыбокского района в амбулаторию общей практики-семейной медицины.
openaire   +1 more source