Results 11 to 20 of about 536,475 (113)

Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-blind clinical trial. [PDF]

BMC Med
Modulating the gut microbiota with prebiotics is a promising strategy for managing metabolic diseases. However, the clinical effects on glycemic metabolism across different populations remain uncertain.
Li J, Liu F, Luo Y, Wijeyesekera A, Wang S, Chen X, Lv Y, Jin J, Sheng H, Wang G, Wei Y, Li Z, Chen M, Zhou H.   +13 more
europepmc   +2 more sources

PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS

Journal of Translational Medicine, 2023
Background Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers.
Zhan-dong Zhang, Liangqun Peng, Wei Yang, Bao-Guang Li, Y. Hua, S. Luo   +5 more
semanticscholar   +1 more source

Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma

Journal of Translational Medicine, 2023
Background Deterioration of normal intestinal epithelial cells is crucial for colorectal tumorigenesis. However, the process of epithelial cell deterioration and molecular networks that contribute to this process remain unclear.
Xiaoqi Huang, Chongyin Han, Jiayuan Zhong, Jiaqi Hu, Yabin Jin, Q. Zhang, W. Luo, R. Liu, Fei Ling   +8 more
semanticscholar   +1 more source

c‐FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma

Clinical and Translational Medicine, 2023
Background The immunomodulatory drug lenalidomide, which is now widely used for the treatment of multiple myeloma (MM), exerts pharmacological action through the ubiquitin‐dependent degradation of IKZF1 and subsequent down‐regulation of interferon ...
N. Osada, J. Kikuchi, H. Iha, H. Yasui, S. Ikeda, N. Takahashi, Y. Furukawa   +6 more
semanticscholar   +1 more source

Single‐cell profiling‐guided combination therapy of c‐Fos and histone deacetylase inhibitors in diffuse large B‐cell lymphoma

Clinical and Translational Medicine, 2022
Background Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphoma. Histone deacetylase inhibitors (HDACis) have been widely applied in multiple tumours, but the expected efficacy was not observed in DLBCL.
Luqiao Wang, Zijuan Wu, Yi Xia, Xueying Lu, Ji Li, L. Fan, C. Qiao, Hai-rong Qiu, Danling Gu, Wei Xu, Jianyong Li, Hui Jin   +11 more
semanticscholar   +1 more source

NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma

Clinical and Experimental Medicine (Testo stampato), 2022
Although several types of calcium channels abnormalities have been shown to promote myeloma bone disease (MBD), the relationship between Na+/Ca2+ exchanger 1 (NCX1) and MBD remains unexplored.
Tingting Li, Dongbiao Qiu, Qingjiao Chen, Apeng Yang, Junmin Chen, Z. Zeng   +5 more
semanticscholar   +1 more source

Acute Hypophagia and Changes in c-Fos Immunoreactivity in Adolescent Rats Treated with Low Doses of Oxytocin and Naltrexone

Journal of Clinical Medicine, 2021
A recent case report has shown that an adjunctive oxytocin + naltrexone (OT + NTX) treatment promoted more robust hypophagia and body weight reduction than OT alone in an adolescent male with hypothalamic obesity after craniopharyngioma resection.
Mitchell Antony Head, Laura K. McColl, A. Klockars, A. Levine, P. Olszewski   +4 more
semanticscholar   +1 more source

Preoperative Esketamine Alleviates Postoperative Pain after Endoscopic Plasma Adenotonsillectomy in Children

Clinical Medicine Research, 2023
Objective: We aimed to investigate preoperative esketamine alleviating postoperative pain in children after endoscopic plasma total adenotonsillectomy.
Feng Liu, Fanli Kong, Liang Zhong, Yan Wang, Z. Xia, Jiang Wu   +5 more
semanticscholar   +1 more source

Treatment with Cenobamate in Adult Patients with Lennox–Gastaut Syndrome: A Case Series

Journal of Clinical Medicine, 2022
Background. Lennox–Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) in which drug resistance to antiepileptic drugs (AEDs) is common. Focal-onset seizures (FOS) are among the seizure types characterizing LGS.
G. Falcicchio, S. Lattanzi, Francesco Negri, M. de Tommaso, A. La Neve, N. Specchio   +5 more
semanticscholar   +1 more source

Network-Based In Silico Analysis of New Combinations of Modern Drug Targets with Methotrexate for Response-Based Treatment of Rheumatoid Arthritis

Journal of Personalized Medicine, 2023
Background: Methotrexate (MTX), sulfonamides, hydroxychloroquine, and leflunomide have consistently resulted in remission with relatively mild to moderate adverse effects in patients with rheumatoid arthritis (RA).
Marjan Assefi, K. Lewandrowski, Morgan P. Lorio, R. Fiorelli, Stefan Landgraeber, Alireza Sharafshah   +5 more
semanticscholar   +1 more source