Results 51 to 60 of about 32,933 (169)

Laryngeal Reinnervation vs Type I Thyroplasty in Unilateral Vocal Fold Paralysis (VOCALIST): A Randomized Feasibility Study

The Laryngoscope, EarlyView.
VOCALIST feasibility study demonstrated that conducting a multi‐centre phase III randomized controlled trial comparing laryngeal reinnervation and type I thyroplasty for unilateral vocal fold paralysis (UVFP) in UK is achievable. Recruitment, randomization, and data collection were successful, and outcome measures for voice, swallowing, and quality of ...
Martin Birchall, Eleftheria Iliadou, Helen Blackshaw, Marcus Jepson, Paul Carding, Samantha Husbands, Kate Heathcote, Marina Mat Baki, Yakubu Karagama, Gareth Ambler   +9 more
wiley   +1 more source

Fabrication of Lithium/Strontium‐Releasing Smart Bioactive Glasses with Anti‐Inflammatory and Osteogenic Effects Tailored to Pathological Stages

Macromolecular Bioscience, EarlyView.
Bioactive glasses with controllable dual ion release capability are developed to aid bone regeneration. The bioactive glasses rapidly release lithium ions that exert an anti‐inflammatory effect, suppressing inflammation after bone injury. Simultaneously, the bioactive glasses slowly release strontium ions, which support bone formation by suppressing ...
Hirohiko Sakai, Jun‐Ichi Sasaki, Haruaki Kitagawa, Gabriela L. Abe, Tomoki Kohno, Naoya Funayama, Satoshi Imazato   +6 more
wiley   +1 more source

Expanding the Allelic and Clinical Heterogeneity of Movement Disorders Linked to Defects of Mitochondrial Adenosine Triphosphate Synthase

Movement Disorders, EarlyView.
Abstract Background Defects of mitochondrial ATP synthase (ATPase) represent an emerging, yet incompletely understood group of neurodevelopmental diseases with abnormal movements. Objective The aim of this study was to redefine the phenotypic and mutational spectrum of movement disorders linked to the ATPase subunit‐encoding genes ATP5F1A and ATP5F1B ...
Philip Harrer, Magdalena Krygier, Martin Krenn, Volker Kittke, Martin Danis, Georgi Krastev, Alice Saparov, Virginie Pichon, Marlène Malbos, Clarisse Scherer, Ivana Dzinovic, Matej Skorvanek, Robert Kopajtich, Holger Prokisch, Sara Silvaieh, Anna Grisold, Maria Mazurkiewicz‐Bełdzińska, Jean‐Madeleine de Sainte Agathe, Juliane Winkelmann, Jan Necpal, Robert Jech, Michael Zech   +21 more
wiley   +1 more source

Natural Peptides Versus Semaglutide: A Safer Approach to Obesity Management

Medicine Advances, EarlyView.
This paper highlights that while semaglutide is effective for weight loss, it is associated with significant side effects, high cost, and muscle loss. In contrast, natural peptides such as BRP, BPC‐157, and MOTS‐c demonstrate promising anti‐obesity effects with fewer adverse outcomes, improved safety profiles, and potential affordability making them ...
Muhammad Affan Abid, Muhammad Babar Asad, Muhammad Junaid Razzak   +2 more
wiley   +1 more source

Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial

Molecular Nutrition &Food Research, EarlyView.
This study explored how a 90‐day nutraceutical blend with prebiotics, minerals, and silymarin affects the gut‐brain axis in overweight adults. Results showed improved gut microbiota, reduced inflammation, and better sleep, mood, and quality of life, suggesting a strong link between gut health and mental well‐being.
Aline Boveto Santamarina, Victor Nehmi Filho, Jéssica Alves de Freitas, Lucas Augusto Moysés Franco, Roberta Cristina Martins, Joyce Vanessa Fonseca, José Antônio Orellana Turri, Mariana Tedesco Hufnagel, Daniel Pecoraro Demarque, Bruna Fernanda Rio Branco da Silva, Arianne Fagotti Gusmão, Eloísa Helena Ribeiro Olivieri, Erica de Souza, Esther Alves de Souza, José Pinhata Otoch, Ana Flávia Marçal Pessoa   +15 more
wiley   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Distortion‐free steady‐state diffusion‐weighted imaging with magnetic resonance fingerprinting

Medical Physics, EarlyView.
Abstract Background Magnetic resonance fingerprinting (MRF) could provide joint T1, T2, and proton density mapping. Measuring diffusion encoding using the MRF framework is promising, given its capacity to generate self‐aligned quantitative maps and contrast‐weighted images from a single scan.
Yiang Wang, Yingying Lin, Di Cui, Edward S. K. Hui, Elaine Y. P. Lee, Peng Cao   +5 more
wiley   +1 more source

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization

The Journal of Pathology, EarlyView.
Abstract Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, its nature remains unclear. This study aims to define the clinicopathological and molecular profiles of a
Antonio Pea, Michele Bevere, Anastasios Gkountakos, Davide Pasini, Denise Fiorini, Andrea Mafficini, Stela Golovco, Michele Simbolo, Serena Pedron, Concetta Sciammarella, Paola Mattiolo, Aldo Mombello, Manuela Villanova, Carlotta Franzina, Francesca Masetto, Calogero Ciulla, Nicola Sperandio, Kohei Fujikura, Masha S. Ahadi, Jaswinder S. Samra, Amber L. Johns, Joanne Verheij, Martijn W.J. Stommel, Hjalmar van Santvoort, Leonor Schubert Santana, Giuseppe Malleo, Michele Milella, Lodewijk A. A. Brosens, Laura D. Wood, David K. Chang, Riccardo De Robertis, Mirko D'Onofrio, Anthony J. Gill, Roberto Salvia, Vincenzo Corbo, Rita T. Lawlor, Aldo Scarpa, Claudio Luchini   +37 more
wiley   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source