Results 61 to 70 of about 32,933 (169)
Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review
Phytotherapy Research, EarlyView.Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley +1 more source
Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle
FASEB BioAdvances, EarlyView.Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn +5 more
wiley +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
Aging Cell, EarlyView.This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu +11 more
wiley +1 more source
A Novel Cognitive Frailty Index for Geriatric Mice
Aging Cell, EarlyView.Our study presents a groundbreaking longitudinal assessment of age‐related cognitive decline in a large cohort of aged mice. Through the development of the Cognitive Frailty Index (CoFI), we introduce a robust metric that correlates strongly with advancing age and mortality.
Serena Marcozzi +16 more
wiley +1 more source
The Journal of Physiology, EarlyView., 2023 Abstract figure legend Reductions in skeletal muscle mitochondrial respiration following 60 days of bed rest explained by a decrease in mitochondrial content, but resulting in an increase in OPA1 and Drp1 mediated mitochondrial fission. Abstract It is unclear how skeletal muscle metabolism and mitochondrial function adapt to long duration bed rest and ...
John Noone +14 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman +5 more
wiley +1 more source
Ethanol‐induced Nrf2 suppression in the lung is mediated by AP‐1‐driven expression of miR‐144
Alcohol, Clinical and Experimental Research, EarlyView.Previously, we determined that ethanol suppresses Nrf2 and thereby inhibits antioxidant and immune defenses in the lung. Clinically, individuals with AUD are vulnerable to pneumonia and acute lung injury. In this new experimental study, we report that ethanol inhibits Nrf2 in rat lung cells via the induction of miR‐144 in a mechanism dependent on the ...
Viranuj Sueblinvong +4 more
wiley +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.ABSTRACT Background Globally, gastric cancer (GC) ranks as the fourth most deadly and fifth most prevalent kind of cancer. Appropriate treatment methods, precise etiology, and molecular processes of GC are still unclear. Methods In silico and quantitative real‐time reverse transcription polymerase chain reaction (qRT‐PCR)‐based expression of miRNA‐27b ...
Yang Dehuo, Wang Ying, Cao Lin
wiley +1 more source
Allergy, EarlyView.We profiled PBMCs in severe asthma patients at baseline and after initiating treatment with mepolizumab or dupilumab. Mepolizumab treatment increases ILC2, Th2, and Tc2 cell frequencies, skewing ILC2 towards CD117low and Th2/Tc2 cells towards a central memory phenotype.
Lorenz Wirth +22 more
wiley +1 more source