Results 151 to 160 of about 4,376 (205)

Electroacupuncture facilitates remote fear memory erasure via promoting perineuronal net degradation. [PDF]

Transl Psychiatry
Teng SW, Guo WB, Song BF, He YZ, Wang KY, Gao SB, Li W, Chen ZY.   +7 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Gene expression alterations in testicular biopsies from males with spermatogenesis arrest identified by transcriptome analysis. [PDF]

PLoS One
Batiha O, Al-Zoubi E, Almomani R, Al Smadi MA, Alrawabdeh S, Alshokaibi O, Abu-Farsakh H, Alkhateeb A, Abu-Halima M.   +8 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Pharmacological and non-pharmacological methods of inducing wakefulness activate distinct neural populations in the mouse brain. [PDF]

PLoS Biol
Maciel R, Malcey J, Gautier K, Chancel A, Duval B, Brunel T, Fort P, Queiroz CM, Luppi PH.   +8 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms. [PDF]

PLoS Biol
Conway PB, Autore L, Muñoz Zamora A, Harel A, Wang Z, Tavallaei AA, Winston SM, Ortega-de San Luis C, O'Leary JD, Brimble MA, Vetere G, Ryan TJ.   +11 more
europepmc   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

Phytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo, Valeria Mazza, Rosamaria Caminiti, Francesca Oppedisano, Saverio Nucera, Salvatore Ragusa, Sara Ilari, Lucia Carmela Passacatini, Luigi Tucci, Giuseppe Trunfio, Vincenzo Mollace, Carolina Muscoli   +11 more
wiley   +1 more source

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain. [PDF]

Elife
Chen Q, Wu H, Xie S, Zhu F, Xu F, Xu Q, Sun L, Yang Y, Xie L, Xie J, Li H, Dai A, Zhang W, Wang L, Jiao C, Zhang H, Zhou X, Xu ZZ, Chen X.   +18 more
europepmc   +1 more source