Results 81 to 90 of about 4,273 (169)

In-Silico discovery of Pediatric Acute-Myeloid-Leukemia (pAML) causing druggable molecular signatures highlighting their pathogenetic processes and therapeutic agents through single-cell RNA-Seq profile analysis. [PDF]

PLoS One
Ahmed MF, Al Noman M, Ahmed MF, Latif MA, Pappu MAA, Islam MS, Hossain MS, Hossen MB, Faysal MF, Hasan MM, Mollah MNH.   +10 more
europepmc   +1 more source

Novel object recognition in the dorsomedial and ventral hippocampus of young domestic chicks (Gallus gallus). [PDF]

Brain Struct Funct
Morandi-Raikova A, Cumplido-Mayoral A, Mayer U.   +2 more
europepmc   +1 more source

Effectiveness of Organized Strategies to Enhance Access to Preventive Oral Cancer Screening Among High‐Risk Individuals in Brazil: A Randomized Clinical Trial in Primary Care

International Journal of Cancer, EarlyView.
This randomized clinical trial evaluated the performance of organized risk‐based strategies to expand access to cancer preventive oral examination among vulnerable populations within the public health system of Rio de Janeiro, Brazil. Compared with an opportunistic approach, the organized invitation‐based oral cancer screening approaches systematically
Marcia Frias Pinto Marinho, Keith Bullia da Fonseca Simas, Patrícia Vinas Heras, Claudia Aparecida Serra da Cruz, Amanda Martins dos Santos Bessa, Mário José Romãnach, Aline Corrêa Abrahão, Maria Augusta Visconti, Michelle Agostini   +8 more
wiley   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day. [PDF]

PLoS Biol
Sun G, Mano T, Shi S, Li A, Ode KL, Rosi-Andersen A, Pedron E, Brown SA, Ueda HR, Kompotis K, Forger DB.   +10 more
europepmc   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

A latent activated olfactory stem cell state revealed by single-cell transcriptomic and epigenomic profiling. [PDF]

Stem Cell Reports
Van den Berge K, Bakalar D, Chou HJ, Kunda D, Risso D, Street K, Purdom E, Dudoit S, Ngai J, Heavner W.   +9 more
europepmc   +1 more source

Prolonged Turnaround Time of the Hematology Laboratory and Related Factors in the South Gondar Zone, North West Ethiopia, Multi‐Centered Study

Journal of Clinical Laboratory Analysis, EarlyView.
Long turnaround times were prevalent in the hematology laboratories of South Gonder zone hospitals, predominantly as a result of staff incompetence. Clotted blood samples, low blood fill levels, and the day of the week were significant factors linked to delays, with samples collected on Friday having a higher likelihood of prolonged turnaround time ...
Birhanemaskal Malkamu, Getaneh Atikilt Yemata, Andargachew Almaw, Ayenew Berhan, Ayenew Assefa, Alemie Fentie, Birhanu Gete, Biruk Legese, Fanta Obsa, Gebyaw Arega, Habtamu Demelash, Tahir Eyayu, Teklehaimanot Kiros, Mahider Shimelis Feyisa, Mulat Erkihun, Mitikie Wondmagegn, Yenealem Solomon, Shewaneh Damtie, Tegenaw Tiruneh, Girum Tesfaye   +19 more
wiley   +1 more source

Chronic random sleep deprivation causes prolonged pain hypersensitivity via the anterior cingulate cortex. [PDF]

iScience
Nakano K, Koga K, Kadoya M, Yamada A, Kobayashi K, Pickering AE, Koyama H, Furue H.   +7 more
europepmc   +1 more source

Biomass Carbon in Harvest Residues of Winter Oilseed Rape Across Fertilizer N Rates: Implications for Carbon Input Estimations in Soil Carbon Models

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Background: Reliable estimation of carbon (C) inputs from above‐ and belowground residues at different yield levels is crucial, as these inputs drive soil organic carbon (SOC) models for C accounting. Aims: This study quantifies C inputs from different components of winter oilseed rape (WOSR) and compares them with estimates from various ...
Ozan Ozkiper, Iris Vogeler, Lars J. Munkholm, Jørgen Eriksen, Johannes L. Jensen   +4 more
wiley   +1 more source