Results 51 to 60 of about 626 (169)

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Made in the shade: Leaf responses of native wildflowers to single‐axis photovoltaic solar energy

PLANTS, PEOPLE, PLANET, EarlyView.
As solar energy expands globally, balancing renewable power generation with biodiversity and ecosystem health has become an urgent challenge. This study investigated how native wildflowers respond at leaf level to the unique microclimates created by rotating solar panels in California's Central Valley.
Yudi Li, Troy Magney, Alona Armstrong, Rebecca R. Hernandez   +3 more
wiley   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, EarlyView.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Improving forest age estimation to understand subtropical forest regrowth dynamics using deep learning image segmentation of time‐series historical aerial photographs

Remote Sensing in Ecology and Conservation, EarlyView.
Accurately estimating forest age is key to understanding how forests recover and evaluating restoration success. We developed a two‐step deep learning approach using historical greyscale aerial photographs to map forest age at fine spatial scales. By combining a pre‐trained model with localized fine‐tuning, our U‐Net + ResNet50 architecture achieved ...
Ying Ki Law, Yi‐Fei Gu, Shuwen Liu, Guangqin Song, Aland H. Y. Chan, Cham Man Tse, Zhonghua Liu, Martha J. Ledger, Billy C. H. Hau, Sawaid Abbas, Jin Wu   +10 more
wiley   +1 more source

Multi‐level fatigue reliability assessment of reinforced concrete railway bridges

Structural Concrete, EarlyView.
Abstract This paper presents a multi‐level reliability framework for assessing the fatigue life of reinforced concrete (RC) railway trough bridges subjected to cyclic loading. The framework incorporates increasing levels of analytical complexity and real‐world data in four steps. First, an analytical model applies S–N curves and the Palmgren–Miner rule
Silvia Sarmiento, Jaime Gonzalez‐Libreros, Chao Wang, Lennart Elfgren, Ola Enoksson, Tommy Höjsten, Lars‐Olof Andersson, Gabriel Sas   +7 more
wiley   +1 more source

Nanomaterials‐Decorated Biomass‐Derived Carbon for Overall Water Splitting: Interfacial Engineering, Mechanistic Insights, and Device Translation

The Chemical Record, EarlyView.
Biomass‐derived carbon provides a sustainable, porous, and conductive scaffold that stabilizes nanomaterials for bifunctional hydrogen evolution reaction/oxygen evolution reaction catalysis. This review summarizes design strategies (defects, heteroatom doping, heterostructures, single atoms), mechanistic/density functional theory insights, degradation ...
Paricha Jebin, Md. Rakib Khan, Syed Shaheen Shah, S. M Mostafa Kamal, Mst. Kaniz Subarna, Nipa Debnath, Md. Abdul Aziz, Bong‐Joong Kim, A. J. Saleh Ahammad   +8 more
wiley   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source