Results 31 to 40 of about 1,285 (110)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Advancing forward osmosis predictions: A deep learning‐based surrogate modeling approach

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6766-6778, 30 August 2026.
Abstract BACKGROUND This study presents a deep learning‐based surrogate model for the rapid and accurate prediction of forward osmosis (FO) performance under diverse operating conditions. To assess the applicability of data‐driven approaches, several machine learning models – decision tree, random forest, support vector machine, and deep neural network
Hyeon Woo Park, Woo‐Ju Kim
wiley   +1 more source

Development of Design‐Phase Digital Twin for Structural Optimization of a Biomedical Device

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 8, August 2026.
A digital twin optimized the structural performance of a multi‐component biomedical device interface by 75%. The work shows that wider adoption of digital twins can accelerate safer, more predictive medical device development across design, verification, and optimization stages.
Tanguy René Pinol, Leon Hugh Prentice, Kate Fox, Toh Yen Pang   +3 more
wiley   +1 more source

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source

A GRACE/‐FO‐Based Framework for Improved Reproduction of Water‐Balance‐Constrained Evapotranspiration Across Hydroclimatic Regimes

Earth and Space Science, Volume 13, Issue 8, August 2026.
Abstract Diagnosing monthly evapotranspiration (ET) under water‐balance constraints is essential for understanding land‐atmosphere interactions and managing water resources under changing climate conditions. Since 2002, the Gravity Recovery and Climate Experiment (GRACE) and its successor GRACE Follow‐On (GRACE/‐FO) missions have provided precise ...
Xiaolong Li, Jürgen Kusche, Taoyong Jin, Yulong Zhong, Benjamin Daniel Gutknecht   +4 more
wiley   +1 more source

Value and moral divergences between management researchers and managers: Evidence and a future research agenda

Applied Psychology, Volume 75, Issue 4, August 2026.
Abstract We know little about the values and morals that management researchers hold and whether they align with a key set of stakeholders they intend to inform—managers in industry. This alignment matters because values and morals serve as guiding principles and are important drivers of attitudes and behavior, and differences in values and morals can ...
Jake B. Telkamp, Marc H. Anderson
wiley   +1 more source

Growth and histomorphological responses of Chindongo socolofi to the long‐term replacement of fish meal with defatted Tenebrio molitor meal

Journal of the World Aquaculture Society, Volume 57, Issue 4, August 2026.
Abstract The long‐term suitability of defatted Tenebrio molitor larvae meal (TM) as a substitute for fish meal (FM) protein was evaluated in Chindongo socolofi over a 170‐day feeding period. Six isonitrogenous (38% crude protein) and isoenergetic (4396 kcal kg−1) diets were formulated, in which TM protein replaced FM protein at 0% (control), 20%, 40 ...
Hasan Batuhan Emre Özdoğan
wiley   +1 more source

Mitigating Black Pod Disease in Cocoa Plants: An Optimal Control and Cost‐Effectiveness Analysis

Natural Resource Modeling, Volume 39, Issue 3, August 2026.
ABSTRACT Black pod disease (BPD), caused by Phytophthora species, continues to pose a significant threat to cocoa production, particularly in tropical regions where cocoa farming is a major economic activity. This study develops a deterministic compartmental model to understand the transmission dynamics of BPD and evaluate the impact of multiple ...
Bernard Asamoah Afful
wiley   +1 more source

Macrophage respiratory complex III governs immune evasion. [PDF]

Immunometabolism (Cobham)
Neumann MA, Frezza C.
europepmc   +1 more source