Results 31 to 40 of about 1,364 (112)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani   +5 more
wiley   +1 more source

Toward an enhanced scalability framework for human‐multi‐agent teams

open access: yesAI Magazine, Volume 47, Issue 4, Winter 2026.
Abstract As autonomous systems become increasingly capable, the deployment of Human‐Multi‐Agent Teams (HMATs) offers immense potential for executing complex, decentralized tasks. However, realizing this potential is constrained by a critical bottleneck: the cognitive and supervisory capacity of the human operator.
Lawrence Dale Perkins   +2 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat   +11 more
wiley   +1 more source

Innovative Field Applications of Probiotics, Prebiotics, and Medicinal Plant Products for Disease Control in Aquaculture

open access: yesJournal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Disease outbreaks and the associated reliance on antibiotics pose major constraints to the sustainability of modern aquaculture. As regulatory pressures increase and consumer demand shifts toward residue‐free production, diverse biological interventions are gaining prominence as viable alternatives to chemotherapeutics.
Mustafa Öz   +5 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, Volume 16, Issue 10, Page 1884-1898, October 2026.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Adeno‐Associated Virus Vector‐Mediated Expression of Neuroligin 2 in the Mouse Hippocampus Attenuates the Progression of Pentylenetetrazol‐Induced Seizures

open access: yesThe Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
Mice received bilateral hippocampal injections of an AAV vector expressing NL2, followed by repeated PTZ administration. NL2 expression in the HPC attenuated seizure progression and reduced c‐Fos expression in the ventral HPC. These findings suggest that AAV‐mediated NL2 expression in the HPC may be a potential therapeutic strategy for seizure control.
Tomohiro Tokutake   +12 more
wiley   +1 more source

Best practices for cryo‐trapping time‐resolved crystallography with the Spitrobot crystal plunger

open access: yesProtein Science, Volume 35, Issue 10, October 2026.
Abstract Capturing meta‐stable conformations of enzymes and ligand complexes demands structural snapshots beyond static crystal structures. While time‐resolved serial crystallography at room temperature offers a time‐resolution down to the femto‐second domain, it requires large amounts of micro crystals, specialized beamlines, and considerable ...
Robert Bosman   +7 more
wiley   +1 more source

Multi‐level fatigue reliability assessment of reinforced concrete railway bridges

open access: yesStructural Concrete, Volume 27, Issue 5, Page 7026-7047, October 2026.
Abstract This paper presents a multi‐level reliability framework for assessing the fatigue life of reinforced concrete (RC) railway trough bridges subjected to cyclic loading. The framework incorporates increasing levels of analytical complexity and real‐world data in four steps. First, an analytical model applies S–N curves and the Palmgren–Miner rule
Silvia Sarmiento   +7 more
wiley   +1 more source

Quantifying Vegetation Dependence on Groundwater: Evidence From Northern China's Drylands

open access: yesWater Resources Research, Volume 62, Issue 10, October 2026.
Abstract Groundwater is a critical source for vegetation in drylands, yet the quantification of vegetation dependence on groundwater (VDG) remains underexplored. Understanding this dependence is essential for unraveling vegetation‐groundwater interactions and informing sustainable water resources management in drylands.
Xing Li   +9 more
wiley   +1 more source

On automorphism groups of metric reduced products of symmetric groups

open access: yesBulletin of the London Mathematical Society, Volume 58, Issue 10, October 2026.
Abstract We study isomorphisms between metric reduced products of symmetric groups with the normalized Hamming metric assuming the open coloring axiom OCA${\mathsf {OCA}}$ and Martin's axiom for σ$\sigma$‐linked posets.
Ben De Bondt, Andreas Thom
wiley   +1 more source

Home - About - Disclaimer - Privacy