Results 41 to 50 of about 4,078 (217)

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

DataSheet1_Landslide mechanism and stability of an open-pit slope: The Manglai open-pit coal mine.docx

, 2023
A clear understanding of landslide mechanisms and stability analyses is of great significance for landslide monitoring, prediction, and control. A large-scale end wall landslide occurred and its area reached 47,752 m2 on August 7–20, 2020, in the Manglai
Tao Chen (75911), Jisen Shu (14421489), Baosheng Li (290758), Gerson. S. V. Tovele (14421492), Liu Han (551277)   +4 more
core   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Tilted fiber bragg grating vibration sensor intended for use in deep-sleep diagnosis

, 2010
This final year report seeks to document that a TFBG inscribed in a SMF and a spliced MMF section is able to detect mechanical vibrations with the exhibition of strong correlation to the frequency of the vibrations. The mechanical vibration or dynamic
Quek, Andrew Zhi Wei.
core  

Analisis Pembebanan Rangka Penopang Tangki IBC Dumping Table Hidrolik

, 2023
Keamanan konstruksi menjadi salah satu tujuan dalam perancangan karena berkaitan dengan faktor keamanan dalam lingkungan kerja. Dumping table merupakan alat bantu yang digunakan dalam proses penuangan oli dari tangki IBC menuju tempat penimbangan ...
Khoryanton, Ampala, Karuniawan, Ardien Devri, Putri, Farika Tono   +2 more
core  

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Chondrocyte response to in vitro mechanical injury and co-culture with joint capsule tissue [PDF]

, 2005
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005.Includes bibliographical references.Acute traumatic joint injury in young adults leads to an increased risk for the development of osteoarthritis (OA) later in ...
Lee, Jennifer H. (Jennifer Henrica)
core  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Topology Optimization and Testing of Connecting Rod Based on Static and Dynamic Analyses

This research article outlines our aim to perform topology optimization (TO) by reducing the mass of the connecting rod of an internal combustion engine based on static structural and dynamic analyses.
Akash Nag, Aleš Slíva, Mahalingam Nainaragaram Ramasamy, Prasath Govindaraj   +3 more
core   +1 more source