Results 71 to 80 of about 99 (99)

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Tumor‐Intrinsic Forkhead Box A2 Regulates the Lymph Node Metastasis of Papillary Thyroid Carcinoma by Regulating T‐Cell Apoptosis

iLABMED, EarlyView.
We identified FOXA2 as a key regulator of lymph node metastasis in thyroid cancer, which controls cancer cell aggressiveness. FOXA2 knockdown promotes metastasis by enhancing tumor cell migration and, importantly, by inducing T‐cell apoptosis through a CCL2/LCN2‐mediated pathway. Created with BioGDP.com.
Ping Yang, Xueying Zhang, Wen Deng, Fangning Gao, Shujia Peng, Guoqiang Bao, Lijuan Yuan   +6 more
wiley   +1 more source

Structural design and property regulation of organic polymers for photocatalytic synthesis of H2O2

InfoScience, EarlyView.
Photocatalytic synthesis of H2O2 offers a sustainable approach. Photocatalytic efficiency depends critically on interfacial electron transfer kinetics and spatial charge separation. Herein, we systematically analyze key factors governing photogenerated carrier dynamics and propose engineered strategies to optimize performance, thereby providing design ...
Mingyang Xu, Rongchen Shen, Yingyin Mo, Guijie Liang, Shijie Li, Peng Zhang, Xiaobo Chen, Youji Li, Xin Li   +8 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Interdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li   +12 more
wiley   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Egg yolk hydrolysate shows moderate impact on osteoporosis in ovariectomized rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND This study investigated the protective effect of egg yolk hydrolysate (FC) on osteoporosis in ovariectomized (OVX) rats, a well‐established model of postmenopausal bone loss. OVX rats were fed diets supplemented with 0.2% or 1% FC for 13 weeks.
Ilekuttige Priyan Shanura Fernando, Da Shi, Zihan Wang, Michael Doschak, Jianping Wu   +4 more
wiley   +1 more source

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

Exploring Thermal and Mechanical Strains During Laying Down Process in Fused Filament Fabrication

Macromolecular Materials and Engineering, EarlyView.
This study analyzes strain evolution and thermal behavior during FFF of PLA using strain gauges and infrared imaging. Microstrain levels depend on printing conditions, with adhesion‐induced compression during cooling and peak strains in early layers. Microtomography shows minimal porosity, while thermal imaging reveals rapid heat penetration, strong ...
Boubakeur Mecheri, Jaianth Vijayakumar, Elodie Boller, Sofiane Guessasma   +3 more
wiley   +1 more source

Hybrid Reaction–Diffusion Epidemic Models: Dynamics and Emergence of Oscillations

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this paper, we construct a hybrid epidemic mathematical model based on a reaction–diffusion system of the SIR (susceptible‐infected‐recovered) type. This model integrates the impact of random factors on the transmission rate of infectious diseases, represented by a probabilistic process acting at discrete time steps.
Asmae Tajani, Cristiana J. Silva, Guillaume Cantin   +2 more
wiley   +1 more source