Results 1 to 10 of about 22,139 (168)

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1-JUN/FOS Axis. [PDF]

Adv Sci (Weinh)
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Ran J, Fang Y, Ruan S, Wang J, Liu S, Mao Y, Hou D, Wang Y, Ye Z, Li Q, Zhang D.   +10 more
europepmc   +2 more sources

Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of Ca² ⁺-CaMK-CREB Signaling in Ventral Tegmental Dopaminergic Neurons. [PDF]

Adv Sci (Weinh)
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Jiang H, Zhou Z, Xue N, Deng J, Zhou Y, Lv X, Wang Y, Zhang Y, Pan H, Xu G, Tao Y, Li M, Cui X, Ma H, Wang Q, Lu Z.   +15 more
europepmc   +2 more sources

The history of astronomy in the books of natural sciences fo the final years of fundamental teaching in PNLD 2017-2019

, 2020
Compreender a Astronomia é mais do que olhar para o conhecimento atual, é também entender como esse conhecimento se desenvolveu. Por isso a História da Astronomia (H-Astro) é imprescindível para a compreensão da construção do conhecimento pelos sujeitos.
Almeida, Adelves de Sousa, Menezes, Maria Cilene Freire de   +1 more
openaire   +1 more source

Nanomaterial-genetics enables near-infrared-driven genetically targeted neuromodulation. [PDF]

Sci Adv
Liu Y, Wang X, Yin W, Chen J, Fan Y, Yang J, Wang Y, Ge L, Rao W, Wang L, Li C, Guo ZV, Liu N, Sun X, Yang Y.   +14 more
europepmc   +1 more source

FOS Regulates Myogenic and Adipogenic Differentiation via Extracellular Matrix Signaling. [PDF]

J Agric Food Chem
Lin W, Li X, Hu W, Zhao X, Wei N, Li Y, Bao Q, Tian C, Liu W, Chen Z, Mai Z, Zhao S, Zhu Y, Zhu G, Huang H, Tang Z.   +15 more
europepmc   +1 more source

Asarinin Inhibits RANKL-Induced Osteoclast Differentiation by Targeting the p38/ERK-c-Fos-NFATc1 Axis. [PDF]

Int J Mol Sci
Zhang L, Xie C, Bao X, Li X, Velez H, Basit F, Ding Y, Tabandeh M, Deepak V.   +8 more
europepmc   +1 more source

Zona incerta somatostatin⁺ neurons modulate seizure progression through hypothalamic circuits. [PDF]

Nat Commun
Zhang M, Yang L, Zhou Y, Ruan Y, Jiang D, Yu L, Ying J, Wang W, Tang T, Li M, Chen Z, Fei F, Xu C, Wang Y.   +13 more
europepmc   +1 more source

Early radiotherapy delays acquired gefitinib resistance in EGFR-mutant NSCLC by suppressing c-FOS-associated survival signaling. [PDF]

Respir Res
Peng L, Gong J, Li Y, Deng S, Li J, Zhang Y, Zhang L.   +6 more
europepmc   +1 more source

Apoptotic cell overload drives multinucleated giant cell formation after neoadjuvant chemotherapy in colorectal cancer: molecular mechanisms and tumor-suppressive effects. [PDF]

Cell Death Dis
Xue J, Wang Z, Zhang X, Xu S, Wu S, Sun X, Li M, Wu X, Chen Z, Lu M.   +9 more
europepmc   +1 more source