Results 151 to 160 of about 20,989 (216)

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source

Lateral Habenula 5-HT₂A Receptors Mediate Social Deficits in a Valproic Acid-Induced Rodent Model of Autism Spectrum Disorder. [PDF]

Mol Neurobiol
Zhang C, Sang H, Zhang B, Zhao Z, Shang H, Wang X, Luan S, Wang J.   +7 more
europepmc   +1 more source

Commercial treaties and political transformation in Sulu and Southeast Asian littorals, c. 1830–1840

Asia‐Pacific Economic History Review, EarlyView.
Abstract This article re‐examines an economic treaty concluded between Spain and the Sulu Sultanate in 1836. Analysing the Tausug (Jawi) and Spanish treaty versions alongside archival sources from Spain, the Philippines, and England, it traces the impact of indigenous agency beyond the formal signatories on economic and political transformations ...
Eleonora Poggio, Ariel Lopez, Birgit Tremml‐Werner   +2 more
wiley   +1 more source

Exploring the Potential Role of Hydroxytyrosol in Androgenetic Alopecia: An Integrated Bioinformatics and Molecular Simulation Study. [PDF]

Int J Mol Sci
Zhang L, An X, Xu M.
europepmc   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Regularized reduced rank regression for mixed predictor and response variables

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract In this paper, we introduce the Generalized Mixed Regularized Reduced Rank Regression model (GMR4), an extension of the GMR3 model designed to improve performance in high‐dimensional settings. GMR3 is a regression method for a mix of numeric, binary and ordinal response variables, while also allowing for mixed‐type predictors through optimal ...
Lorenza Cotugno, Mark de Rooij, Roberta Siciliano   +2 more
wiley   +1 more source

The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents. [PDF]

Sci Adv
Zheng L, Pan L, Fu X, Wang 王思羽 S, Wu Y, Xiao H, Yang J, Wang 王思雨 S, Yang L, Wu X, Pan F, Yang H, Chen G, Wang H, Wang H.   +14 more
europepmc   +1 more source

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Overexpression of IGF2 Alters the Transcriptional Profile of Goose Skeletal Muscle Satellite Cells. [PDF]

Biomolecules
Wang C, Liu Y, Yang Y, Chen S, He D.
europepmc   +1 more source

A cDC1‐NK/T‐Malignant Cell Circuit Drives Immunogenic Remodeling Under PD‐1 Blockade in Gastric Cancer

Cancer Science, EarlyView.
Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Keita H. Nagaoka, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Yuko Ishii, Sai M. Pulukuri, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source