Results 161 to 170 of about 20,989 (216)

Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice. [PDF]

J Headache Pain
Ren X, Qiu XT, Li YY, Tan CY, Zhou LX, Ye XN, Li L, Huang FS, Zhang FX, Li YQ, Zhang MM.   +10 more
europepmc   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice. [PDF]

Elife
Zhang J, Yu K, Zhang J, Chang Y, Sun X, Qian Z, Sun Z, Qiao Y, Liu Z, Ren W, Han J.   +10 more
europepmc   +1 more source

Understanding the Link Between Social Support Networks, Self‐Efficacy and Future Orientation During Emerging Adulthood: A Comparison of At‐Risk and Non‐at‐Risk Emerging Adults

Child &Family Social Work, EarlyView.
ABSTRACT At‐risk emerging adults may be less inclined to invest in future goals, yet the mechanisms underlying their future orientation (FO) remain unclear. Therefore, this study examined how social support network attributes contribute to FO in at‐risk and non‐at‐risk emerging adults and the mediating role of self‐efficacy.
Eran P. Melkman, Yafit Sulimani‐Aidan
wiley   +1 more source

Uncovering the Key Circuit FOSL2/FOS/EGR3/EGR1, Contributing to the Hyperexcitability of Excitatory Neurons in the Epileptic Temporal Cortex and Hippocampus. [PDF]

Int J Mol Sci
Chen J, Zhao B, Yang K, Mi W, Huang X, Jiang W, Hu C, Wang Z, Zhang Y, Li X.   +9 more
europepmc   +1 more source

Rethinking areas of endemism and barriers: perspectives for a causal historical biogeography and a critique of Schultz and Cracraft (2024)

Cladistics, EarlyView.
Abstract Historical biogeography faces a persistent conceptual and methodological dilemma concerning the nature of its central analytical units. Using the recent proposal by Schultz and Cracraft (Cladistics 40, 653) as a catalyst, this article critiques the argument that causal inference necessitates the replacement of areas of endemism with barriers ...
Augusto Ferrari
wiley   +1 more source

miR-155-5p promotes osteosarcoma progression and cisplatin resistance by targeting the SOCS1/STAT1/c-Fos signaling axis. [PDF]

Discov Oncol
Lu J, Ren H, Song W, Xie S, Li X.
europepmc   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Substance P-expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus-airway neural pathway. [PDF]

Front Neurosci
Zhang X, Chen J, Lin C, Xiao T, Wu B, He F.   +5 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source