Results 111 to 120 of about 486 (170)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Challenges and limitations in using bacterial metabolites as immunomodulators. [PDF]

Front Cell Infect Microbiol
Saravanan C, Gopinath NK, Ganesan R, Thirumurugan D.   +3 more
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Landscape of resistance to ceftolozane/tazobactam and ceftazidime/avibactam in strains of Pseudomonas aeruginosa: a genomic approach in strains without selection pressure in a tertiary-care paediatric hospital in Mexico. [PDF]

BMC Infect Dis
A Méndez HE, Merida-Vieyra J, Aparicio-Ozores G, Hernández-Durán M, Méndez-Tenorio A, Tapia-Reyes A, Bautista-Hernandez R, Juárez-Hinojos D, Aquino-Andrade A.   +8 more
europepmc   +1 more source

Formation Control With Obstacle Avoidance of Underwater Swarms Based on Relative Visual Feedback

Journal of Field Robotics, EarlyView.
ABSTRACT Underwater multi‐robot and swarm systems require advanced methodologies for controlling collective behavior. Conventional single‐robot techniques, such as tethering, sonar imaging, and acoustic localization, are not scalable or effective for swarm applications.
Andrea Infanti, Saverio Iacoponi, Saif Alameri, Mohamed El Hanbaly, Mohammed Tarnini, Cesare Stefanini, Giulia De Masi, Federico Renda   +7 more
wiley   +1 more source

Characterization of the Signaling Pathways Activated by KCl-Induced RTK Stimulation in Guinea Pig Airways. [PDF]

Biology (Basel)
Herrera-Alcibar E, Flores-Soto E, López RM, Castillo EF, Campos-Bedolla P, Carbajal V, Sommer B.   +6 more
europepmc   +1 more source

Agrivoltaic Lettuce Production Under Future Climates: A Sustainable Strategy for Optimizing Food and Energy Yields

Sustainable Development, EarlyView.
ABSTRACT Food system resilience is increasingly challenged by climate change and global trade volatility, even in high‐income nations like Canada. Agrivoltaics—co‐locating crops and photovoltaics (PV)–offers a sustainable production strategy to optimize land use and address both food and energy security.
Uzair Jamil, Linda Alrayes, Eric Fordjour, Raymond Thomas, Joshua M. Pearce   +4 more
wiley   +1 more source

From Xenobiotic Exposure to Neuroinflammation: Mechanisms Linking Lipopolysaccharide Signaling to Depressive-like Behavior. [PDF]

J Xenobiot
Martins AMO, da Silva Soares MF, Oliveira LN, Barbosa NMMV, Matos ALLS, Ferreira Gonçalves MC, Oliveira-Golzio AMF, Bezerra Felipe CF, Scotti MT, Silva PRD, Scotti L.   +10 more
europepmc   +1 more source

Electroconductive MXene‐Thin‐Film‐Composite Membranes for Coupled Osmotic Concentration and PFAS Mineralization

Small, EarlyView.
An electroconductive MXene‐TFC membrane integrates osmotic dewatering with anodic oxidation to concentrate and mineralize PFOA at the membrane interface. The coupled AO‐PRO configuration accelerates degradation kinetics, achieves 99% rejection and up to 93% TOC removal, and lowers specific energy demand, offering a compact route for PFAS destruction ...
Afrouz Yousefi, Pooria Karami, Vahid Rad, Amir Aghaei, Mojtaba Mohseni, Lingling Yang, Masoud Soroush, Matthias Wessling, Mohamed Gamal El‐Din, Mohtada Sadrzadeh   +9 more
wiley   +1 more source

Perspectives of stakeholders on post-trial access arrangements in Ethiopia: a qualitative study. [PDF]

Glob Bioeth
Tucho GT, Wangamati CK, Kumsa DM, Bernabe RC.   +3 more
europepmc   +1 more source