Results 11 to 20 of about 99 (97)

Topology Optimization Enables Freeform Matrix Fourier Optics

Advanced Optical Materials, EarlyView.
A topology‐optimized freeform metasurface is designed and fabricated to realize matrix Fourier optics, enabling the diffraction of multiple polarization states into distinct far‐field orders. By combining forward design with gradient‐based inverse optimization, high polarization contrast of up to 98.7% is achieved.
Yu‐Tzu Liu, Yun‐Chien Wu, Chang‐Yi Lin, Huan‐Teng Su, Yu‐Qi Zhou, Yao‐Wei Huang   +5 more
wiley   +1 more source

Fully Printed Variable Orifice Flowmeter with Built‐In Temperature Compensation for Application in Mechanical Ventilation

Advanced Sensor Research, EarlyView.
Additive manufacturing, specifically fused deposition modeling, offers an innovative approach to creating 3D‐printed variable orifice flowmeters with integrated temperature compensation. Using carbon‐black TPU, the primary component (a variable orifice) and the secondary element (a diaphragm pressure sensor) are fabricated.
Vincenzo Saroli, Emiliano Schena, Carlo Massaroni   +2 more
wiley   +1 more source

Dual Charge Transfer Mechanisms in Intimately Bonded S‐scheme Heterojunction Photocatalyst with Expeditious Activity toward Environmental Remediation

Advanced Sustainable Systems, EarlyView.
A novel MBOdCN S‐scheme heterojunction photocatalyst is fabricated using pristine Mg‐Bi2O3 and grayish g‐C3N4, where dynamic dual charge migration paths occur to accelerate exciton dissociation. This composite catalyst realizes high degradation efficiency of up to 99.56% of oxytetracycline (OTC) removal under optimized conditions. The material exhibits
Potlako J. Mafa, Mope E. Malefane, Francis Opoku, Adewale O. Oladipo, Gcina Mamba, Tunde L. Yusuf, Jemal Fito Nure, Sogolo L. Lebelo, Dan Liu, Jianzhou Gui, Bhekie B. Mamba, Alex T. Kuvarega   +11 more
wiley   +1 more source

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

Advanced Science, Volume 12, Issue 17, May 8, 2025.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp, Ryun Hee Kim, Adithyan Jayaraman, Nils Klement, Raymond Kostlan, Chang H. Kim   +5 more
wiley   +1 more source

Temporal Association Cortex Gates Sound‐Evoked Arousal from NREM Sleep

Advanced Science, Volume 12, Issue 12, March 27, 2025.
It is often wondered why some sounds wake people while others don't. Researchers have discovered that the temporal association cortex plays a key role in this during NREM sleep. Neurons in this region work with the amygdala to decide which sounds are important enough to interrupt sleep, providing a balance between rest and responsiveness.
Haipeng Yu, Jincheng Wang, Ruiqi Pang, Penghui Chen, Tiantian Luo, Xuan Zhang, Yatao Liao, Chao Hu, Miaoqing Gu, Bingmin Luo, Zhiyue Shi, Mengyao Li, Yueting Zhang, Qiaoqian Wei, Wei Yuan, Hui Xie, Zhiyi Chen, Hongbang Liu, Shuancheng Ren, Xiaowei Chen, Yi Zhou   +20 more
wiley   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Artificial Gold Enzymes Using a Genetically Encoded Thiophenol‐Based Noble‐Metal‐Binding Ligand

Angewandte Chemie, Volume 137, Issue 12, March 17, 2025.
A new class of artificial metalloenzymes containing genetically encoded noble‐metal‐binding sites featuring a non‐canonical thiophenol‐based amino acid, which serves as an excellent soft ligand for binding various noble metals, was developed. The corresponding gold(I) enzyme was characterised, confirming gold binding to the thiophenol, and successfully
Mathijs J. Veen, Friso S. Aalbers, Henriëtte J. Rozeboom, Andy‐Mark W. H. Thunnissen, Daniel F. Sauer, Gerard Roelfes   +5 more
wiley   +2 more sources

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel

Advanced Science, EarlyView.
An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu, Yandi Zhou, Shuang Yao, Ziyi Wang, Sihao Ye, Rubing Qi, Hai Hu, Keke Liu, Yabo Wu, Tom Lawson, Lu Yan, Yong Liu, Wencan Wu   +12 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

Advanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan, Han‐Wen Gu, Yan‐Bo Zhou, Sophie Ma, Daqing Ma, Pan‐Miao Liu, Jian‐Jun Yang   +6 more
wiley   +1 more source