Results 11 to 20 of about 4,688 (101)
Advanced Science, EarlyView.This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song +24 more
wiley +1 more source
Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice
Advanced Science, EarlyView.PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu +8 more
wiley +1 more source
Advanced Science, EarlyView.A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song +16 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang +8 more
wiley +1 more source
Research advances in dysphagia animal models
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai +5 more
wiley +1 more source
Journal of the Association for Information Science and Technology, EarlyView.Abstract There has been a notable increase in bibliometric research studying gender in academia. This narrative review aims to organize and synthesize this extensive body of work to uncover new insights into gender disparities in science. We begin by analyzing key methodological elements, including gender assignment techniques, units of analysis, and ...
Elvira González‐Salmón +2 more
wiley +1 more source
The Effect of Self‐Concept Components on Sustainable Food Choice
Business Strategy and the Environment, EarlyView.ABSTRACT Despite the growing global adoption of sustainable food consumption, the role of self‐concept (including self‐esteem, self‐image, and ideal self) and mindset (beliefs about personal growth and adaptability) in shaping these choices remains underexplored.
Hassan Rahnama Haratbar +2 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective The AMPA study (Study 501; NCT04257604) was a multicenter, prospective, 12‐month observational study in Italy that evaluated the effectiveness and safety of adjunctive perampanel in patients with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS).
Alfredo D'Aniello +24 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.This study explored how a 90‐day nutraceutical blend with prebiotics, minerals, and silymarin affects the gut‐brain axis in overweight adults. Results showed improved gut microbiota, reduced inflammation, and better sleep, mood, and quality of life, suggesting a strong link between gut health and mental well‐being.
Aline Boveto Santamarina +15 more
wiley +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim Determination of faecal gluten immunogenic peptides (f‐GIP) has recently been proposed as new noninvasive method to detect gluten intake in celiac disease (CD). Our aim was to evaluate the use of f‐GIP for the adherence to gluten‐free diet (GFD) and to compare this new marker with traditional methods.
Sabrina Cenni +8 more
wiley +1 more source