Results 51 to 60 of about 583,200 (160)

Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential

Developmental Neurobiology, Volume 86, Issue 1, January 2026.
ABSTRACT Adult patterns of behavior can often be explained by developmental experiences. In some cases, developmental experience can have permanent influence on brain and behavior only during specific ages; these phases are called critical or sensitive periods. Epigenetic mechanisms can regulate both maturational and experiential processes in the brain
Grant W. Kunzelman, Alice Batistuzzo, Sarah E. London   +2 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Activation of Calcium/Calmodulin‐Dependent Kinase II in the Medial Prefrontal Cortex Mediates Spinal Cord Injury‐Related Cognitive and Affective Changes

Brain and Behavior, Volume 15, Issue 12, December 2025.
Research has documented a high prevalence of cognitive and affective impairments in individuals with spinal cord injury (SCI). Our findings suggest that CaMKII activation in the mPFC might play an important role in mediating negative emotional states following SCI.
Jian Qi, Chen Chen, Qian Gao, Sheng Sun
wiley   +1 more source

Perceptions of “Healthy Life Expectancy” of Individuals With Diseases: An Online Survey in Japan

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims In Japan, discussions around healthy life expectancy (HLE) are often focused on prevention of diseases or disabilities. However, the advancements in medical technologies have led to an increase in the number of individuals living with these conditions. The aims of this study are (1) to compare the perceptions of HLE between
Kyunghee Lee, Kazumi Ota, Tetsuya Toma, Masako Toriya   +3 more
wiley   +1 more source

Making Sense of Erotically Oppressive Lifeworlds: Dynamics of Testimonial Smothering and Testimonial Quieting

Journal of Social Philosophy, EarlyView.
Paul Giladi
wiley   +1 more source

Dysbiosis and Therapeutic Modulation of the Gut Microbiota in Multiple Sclerosis: A Narrative Review

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Multiple sclerosis (MS) is a persistent autoimmune disease that affects the central nervous system. The etiology of MS is complex, involving a variety of genetic and environmental factors. Mounting evidence suggests that dysbiosis significantly impacts the progression of MS mainly through its direct effects upon the immune ...
Mojtaba Memariani, Hamed Memariani
wiley   +1 more source

MOMMY study profile: An integrative early‐life multi‐omics cohort in China

iMetaOmics, Volume 2, Issue 4, December 2025.
MOMMY cohort (The MOther‐infant Microbiota transmission and its link to long terM health of babY) is a large, prospective birth cohort uniquely designed to investigate maternal‐paternal‐infant microbiota transmission and its impact on child health within the understudied Chinese population.
Lin Zhang, Yingzhi Liu, Shilan Wang, Jessica Yuet‐Ling Ching, Wing Hung Tam, Ting Fan Leung, Tak Yeung Leung, Paul K. S. Chan, Joyce W. Y. Mak, Chun Pan Cheung, Hein Min Tun, Eugene B. Chang, Orlando DeLeon, Qitao Huang, Xiaoqian Chen, Huiyi Huo, Yinglei Miao, Pui Kuan Cheong, Ka Long Ip, Yuk Ling Yeung, Mei Kam Chang, Chunmei Lyu, Hongju Yang, Bona Li, Yushuo Fan, Yang Sun, Suhua Jiang, Siew Chien Ng, Francis Ka Leung Chan   +28 more
wiley   +1 more source

Progression and Metastasis of Lung Cancer: Clinical Features, Molecular Mechanisms, and Clinical Managements

MedComm, Volume 6, Issue 12, December 2025.
Lung cancer represents a significant global health threat. Despite progress in treatment, metastasis continues to present a major clinical challenge. This article reviews the metastases of lung cancer to the liver, bone, and brain, focusing on clinical symptoms, molecular mechanisms, and treatment strategies.
Yunkui Zhang, Meixi Chen, Xumeng Fang, Yu Han, Yingke Li   +4 more
wiley   +1 more source

Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu, Xiao‐Mei Wu, Yan Hu, Xiao‐Lan Bian, Ya‐Qin Wang, Qiong‐Ni Zhu   +5 more
wiley   +1 more source