Results 181 to 190 of about 499,874 (389)

A Generalizable Transformer Framework for Gene Regulatory Network Inference from Single‐Cell Transcriptomes

open access: yesAdvanced Intelligent Systems, EarlyView.
FTGRN introduces an LLM‐enhanced framework for gene regulatory network inference through a two‐stage workflow. It combines a Transformer‐based model, pretrained on GPT‐4 derived gene embeddings and regulatory knowledge, with a fine‐tuning stage utilizing single‐cell RNA‐seq data.
Guangzheng Weng   +7 more
wiley   +1 more source

AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression [PDF]

open access: gold
Shanbang Zhu   +9 more
openalex   +1 more source

Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN–FOS at composite DNA sites [PDF]

open access: hybrid, 2018
Bethany J. Madison   +5 more
openalex   +1 more source

Enhancing c‐fosmRNA Expression in Primary Cortical Cell Cultures with a Dynamic Magnetic Fields Device [PDF]

open access: bronze, 2023
Takashi Shibata   +5 more
openalex   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo   +8 more
wiley   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

open access: yesAdvanced Science
The transcription factor c‐Fos plays a key role in liver metabolism, stress responses, and carcinogenesis. Here, the role of hepatic c‐Fos in the pathophysiology of metabolic dysfunction‐associated steatotic liver disease and hepatocellular carcinoma ...
Ao Li   +8 more
doaj   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

open access: yesAnnals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang   +10 more
wiley   +1 more source

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