Results 121 to 130 of about 36,369 (248)

An Efficient, One-Pot Synthesis of Fosfomycin Dialkyl Esters from (R)-2-Tosyloxypropanal [PDF]

, 2007
(R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot,
Hanaya, Tadashi, Nakamura, Yuichi, Yamamoto, Hiroshi   +2 more
core   +1 more source

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng, Hua Wang, Li Zhang, Shiping Li, Yuan Yuan, Mengting Tian, Yi Qu, Junjie Ying, Meicen Zhou, Yong Hu, Jinglan Huang, Rong Zou, Fengyan Zhao, Xiaojuan Su, Qian Liu, Yan He, Jinxing Feng, Weimin Huang, Ying Luo, Zhemin Zhou, Wei Shen, Dezhi Mu, Shaopu Wang   +22 more
wiley   +1 more source

Exploring dangerous connections between Klebsiella pneumoniae biofilms and healthcare-associated infections [PDF]

, 2014
Healthcare-associated infections (HAI) are a huge public health concern,particularly when the etiological agents are multidrug resistant. The ability of bacteria to develop biofilm is a helpful skill, both to persist within hospital units and to ...
Bandeira, Maria, Carvalho, Patricia Almeida, Duarte, Aida, Jordão, Luísa   +3 more
core   +2 more sources

Antibacterial Efficacy of Two Commercially Available Bacteriophage Formulations, Staphylococcal Bacteriophage and PYO Bacteriophage, Against Methicillin-Resistant Staphylococcus aureus: Prevention and Eradication of Biofilm Formation and Control of a Systemic Infection of Galleria mellonella Larvae [PDF]

, 2020
Sessile bacteria growing on surfaces are more resistant to standard antibiotics than their planktonic counterpart. Due to their antimicrobial properties, bacteriophages have re-emerged as a promising approach to treat bacterial biofilm-associated ...
Di Luca, Mariagrazia, Tavanti, Arianna, Tkhilaishvili, Tamta, Trampuz, Andrej, Wang, Lei   +4 more
core   +1 more source

Case Report: Omadacycline in the Treatment of Community‐Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Omadacycline, a novel once‐daily aminomethylcycline antibiotic agent, demonstrates efficacy against prevalent pathogens responsible for community‐acquired pneumonia (CAP) in adults. However, the safety and efficacy of omadacycline in younger children have not yet been established.
Ziqi Xu, Wen Pan, Hui Lei, Chen Dong, Biao Zou, Sainan Shu, Wenting Zhang   +6 more
wiley   +1 more source

Identification of a novel chromosome-encoded fosfomycin resistance gene fosC3 in Aeromonas caviae

Frontiers in Microbiology
BackgroundOwing to the rapid emerging of multidrug-, even pandrug-resistant pathogens, and lack of new antibiotics, the older antibiotic, fosfomycin, has been reused in recent years in the clinical practice, especially for treatment of uropathogen ...
Junwan Lu, Junwan Lu, Runzhi Zhang, Yan Yu, Hongqiang Lou, Dong Li, Qiyu Bao, Qiyu Bao, Chunlin Feng   +8 more
doaj   +1 more source

Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2016
Fosfomycin is a new agent to Canada approved for the treatment of acute uncomplicated cystitis (AUC) in adult women infected with susceptible isolates of E. coli and Enterococcus faecalis.
George G. Zhanel, Andrew J. Walkty, James A. Karlowsky   +2 more
doaj   +1 more source

Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals [PDF]

, 2015
This study investigated 248 extended-spectrum β-lactamase-producing Escherichia coli isolates from 2012 to 2013 for hybrid blaCTX-M genes. blaCTX-M genes were detected in 228 isolates of which 14 isolates were hybrid blaCTX-M positive (6 blaCTX-M-123, 6 ...
Chow, KH, Ho, PL, Lai, ELY, Lau, TCK, Law, OK, Liu, MCJ, Lo, WU   +6 more
core   +1 more source

Fosfomycin susceptibility of uropathogens at Charlotte Maxeke Johannesburg Academic Hospital

Southern African Journal of Infectious Diseases, 2020
Background: Multidrug-resistant uropathogens are becoming widespread both in community and hospital setting. Safe yet effective treatments are a priority.
Lesego M. Mothibi, Norma N. Bosman, Trusha Nana   +2 more
doaj   +1 more source

Antibiotic Use in Livestock: A Driver of Resistance in Africa and the Path to Safer Alternatives

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The incorporation of antibiotics into animal feeds is one of the drivers of antibiotic resistance, a global One Health challenge. To reduce the burden of antibiotic resistance, the use of alternative growth promoters and drugs must be promoted, as well as sensitization and implementation of regulations.
Mercy A. Alabi, Hafizah Y. Chenia, Johnson Lin   +2 more
wiley   +1 more source