Results 21 to 30 of about 4,788,837 (287)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

All-cause mortality following internal fixation for isolated fractures in non-polytrauma admissions: a comprehensive 10-year nationwide linked data retrospective cohort study

BMJ Open
Introduction Skeletal fractures are a leading cause of death and disability and a growing global public health concern. Internal fixation is a common surgical treatment indicated for several fractures, yet there are few comprehensive epidemiological ...
Alex Bottle, Paul Aylin, Omar Musbahi, Caroline Hing, Walter Muruet   +4 more
doaj   +1 more source

Factors associated with hospital emergency readmission and mortality rates in patients with heart failure or chronic obstructive pulmonary disease: a national observational study

Health Services and Delivery Research, 2018
Background: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) lead to unplanned hospital activity, but our understanding of what drives this is incomplete.
Alex Bottle, Kate Honeyford, Faiza Chowdhury, Derek Bell, Paul Aylin   +4 more
doaj   +1 more source

FACTORS CONTRIBUTING TO THE BREAKDOWN OF FOSTER CARE PLACEMENTS: THE PERSPECTIVES OF FOSTER PARENTS AND ADOLESCENTS

Social Work/Maatskaplike Werk, 2016
This article describes the factors contributing to the breakdown of foster care placements of adolescents from the perspective of the foster parents and adolescents involved.
Mnisi, Rosina , Botha, Petro
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Temporal trends in the prevalence and causes of visual impairment in the South Indian state of Telangana: a population-based cross-sectional study

BMJ Open, 2019
Objectives To investigate the temporal trends in the prevalence and causes of visual impairment (VI) in South India.Design Population-based cross-sectional studies conducted during the years 2011–2012 and 2017 using identical study methods and in ...
Srinivas Marmamula, Rohit C Khanna, Shashank Yellapragada, Rajesh Challa, Javed Mohd, Gullapalli Nageswara Rao   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

PREPAREDNESS FOR EMANCIPATION OF YOUTH LEAVING ALTERNATIVE CARE IN SERBIA

International Journal of Child, Youth & Family Studies, 2018
The process of preparing young people for leaving alternative care is not sufficiently researched in Serbia. In order to define what support is necessary for their successful emancipation, this study of 150 young people in care aims to analyse both their
Anita Burgund Isakov, Jasna Hrnčić
doaj   +1 more source

Follicular Helper T (TFH) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients

Frontiers in Immunology, 2021
Identifying signaling pathways that induce B cell response can aid functional cure strategies for chronic hepatitis B infection (CHB). TLR8 activation with ssRNA was shown to enhance follicular helper T cell (TFH) function leading to improved B cell ...
Natarajan Ayithan, Lydia Tang, Susanna K. Tan, Diana Chen, Jeffrey J. Wallin, Simon P. Fletcher, Shyam Kottilil, Bhawna Poonia   +7 more
doaj   +1 more source