Results 31 to 40 of about 4,788,837 (287)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Voices in Bioethics, 2014 In April of 2001, I visited Emmanuel A. at the Incarnation Children’s Center (“ICC”). Emmanuel was one of my first clients.1 He had come into foster care at birth. His mother was young, a recent immigrant, addicted to heroin, and living in poverty.
Adira Hulkower
doaj +1 more source
What is work? Insights from the evolution of state foster care [PDF]
, 2013 This article focuses on state foster care as a case study in the (re)configuration and negotiation of boundaries between work and non-work. Foster care can be seen as occupying a liminal position between the domains of ‘work’ and ‘family’, requiring ...
Kirton, Derek
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Social Work and Society, 2017 This paper presents a brief synthesis of learning from recently published European foster care research, focussing especially on papers given at the 2015 Siegen foster care research conference.
June Thoburn
doaj +2 more sources
VIEWS OF FOSTERCHILDREN ABOUT CONTACTS WITH PARENTS AND RELATIVES
Human Research in Rehabilitation, 2016 This paper presents the results of research on the views of children about contacts with their birth parents and relatives. The views of children are seen through their experience in contacts and the wishes of children that relate to future contacts ...
Ljiljana Skrobić
doaj
Foster care in context: an evaluation of the foster care communication and recruitment strategy [PDF]
, 2012 This report makes important recommendations to ensure the ongoing efficiency and effectiveness of Victorian approaches to foster care publicity and recruitment.
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source