Results 31 to 40 of about 106,028 (235)
Socio-perceptual images as regulators of child-parental relations in foster families
Социальная психология и общество, 2021 Objective. Definition of communications of I-images of mothers with He-images of the own children, I-images of the foster mothers with He-images of foster children became the purpose of our research; establishment of communications of I-images of the ...
Sitnikov V.L. +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Вестник университета, 2022 The article discusses a special and effective form of living arrangements for the elderly and disabled in a foster family in the regional entities of the Russian Federation. The experience of organizing a foster or substitute family has been developed in
R. M. Sadykov, N. L. Bolshakova
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Being a Foster Family in Portugal—Motivations and Experiences
Societies, 2017 Foster care is an almost absent component in the child care system and scientific research conducted in Portugal foster comprises 3.2%1 of out-of-home care in Portugal. This research aims to contribute to a deeper visibility of the care phenomena, giving
Elisete Diogo, Francisco Branco
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Children, 2021 Children in foster care have a high prevalence of attention deficit and hyperactivity disorder (ADHD) diagnosis, together with other difficulties in inattentive/hyperactive behaviors, executive and cognitive processes.
María Peñarrubia +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Adaptation Issues in Disabled Children Deprived of Parental Care, Living in Foster Families
Психологическая наука и образование, 2017 The paper focuses on revealing psychological issues in the adaptation of children, including the ones with disabilities, which are deprived of parental care and are raised in foster families.
Shulga T.I.
doaj +1 more source