Results 91 to 100 of about 420,357 (288)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The right to freedom : a view from the perspective of fundamental rights
Revista do Direito Público, 2012 The man himself is free . Freedom is born with the human being , however, imposed restrictions on the freedom of man because of his opçãode live in society.
Thiago Ruiz
doaj +1 more source
City of Conrad, Independent Auditor's Reports, Basic Financial Statements and Supplementary Information, Schedule of Findings, June 30, 2004 [PDF]
, 2005 City Audit ...
core
Thermal Analysis and Modeling of Steady-State Rod Growth During Gas-Phase Solid Freeform Fabrication [PDF]
, 1993 An analysis ofthe steady-state growth ofrods during gas-phase solidfreeform fabrication is presented. It is demonstrated that heat transfer controls the evolution ofshape during laser-induced pyrolysis of slender 3-D structures.
Maxwell, James L., Pegna, Joseph
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Fiscal Update, October 5, 2005 [PDF]
, 2005 The Fiscal Division newsletter, published weekly during session and periodically during the ...
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Journal of Marine Science and EngineeringThe expansion of offshore renewable energy development in Portugal necessitates accurate geological and geotechnical site characterization, especially in regions with limited baseline information. This study focuses on the S.
Joaquim Pombo +2 more
doaj +1 more source