Results 71 to 80 of about 69,584 (260)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Islamic Culture, 2020 Banking industry acts as mean of support of contemporary trade and business, stand-in as a link, to endow with a key foundation of monetary intermediation.
Nighat Moin +2 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
On the Characters of the bad Foundation Depositing River and Lake
Journal of the Japan Society of Engineering Geology, 1971 It is needless to say that the characters of stiff foundation depend upon the original state in which the foundation was flexible. Hereupon, in order to solve the problems concerning bad foundation, the writer studied the flexible soils that (deposited in fresh water lakes called by the names of Shinji, Jinjai and Hii-Reservoir.As the results of this ...
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
南方能源建设[Objective] With the promotion of carbon peak and carbon neutrality strategy, offshore wind power has ushered in a period of rapid growth. In 2023, more than 87 offshore wind power project sites in various provinces and cities across the country have ...
Jianjun CHEN
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The right to freedom : a view from the perspective of fundamental rights
Revista do Direito Público, 2012 The man himself is free . Freedom is born with the human being , however, imposed restrictions on the freedom of man because of his opçãode live in society.
Thiago Ruiz
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source