Results 91 to 100 of about 69,584 (260)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Bedrock geochemical baseline and pre-mining risk assessment of heavy metals in a potential lithium deposit in Sonora, Mexico: Implications for sustainable resource management

Environmental and Sustainability Indicators
The clay-hosted lithium deposit in Sonora, Mexico, represents a potential mining site for this critical mineral, which is essential for clean energy technologies and currently in high demand during the energy transition.
Xochitl Virginia Bello-Yañez, María-Concepción Martínez-Rodríguez, S.B. Sujitha, L.E. Campos-Villegas, Diego Domínguez-Solís, Héctor Guadalupe Ramírez-Escamilla, Ana Laura Cervantes-Najera, M.P. Jonathan   +7 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Iron Keys Deposited in the Foundation of Glasgow Bridge

Proceedings of the Society of Antiquaries of Scotland
John Buchanan, a corresponding member of the Society, wrote to inform them of two large iron keys that were found deposited in the foundations of the ancient bridge of the River Clyde.
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Uji Beban dan Analisis Lendutan Model Pelat Fleksibel yang Didukung Tiang-Tiang pada Tanah Pasir

Semesta Teknika, 2015
Sand commonly has a good bearing capacity. Problems may occur when sand has low density and thick deposit. Flexible plate foundation may be used in this soil but plate deflection may be still high.
Edi Hartono
doaj  

Research on the Prediction of Concealed Uranium Deposits Using Geo-Electrochemical Integrated Technology in the Guangzitian Area, Northern Guangxi, China

Applied Sciences
To achieve a significant breakthrough in the exploration of uranium resources in the Guangzitian area of northern Guangxi, China, an innovative combination of exploration methods was implemented at the peripheral regions of the Guangzitian uranium ...
Xiaohan Zhang, Meilan Wen, Qiaohua Luo, Yunxue Ma, Yuheng Jiang, Yuxiong Jiang, Wei Ye, Jiali Zhang   +7 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source