Results 51 to 60 of about 69,876 (261)

Local government interventions for improving the health and wellbeing of tenants in private rented housing: developing initial program theory to inform evaluation in the United Kingdom

BMC Public Health
Background Housing is an important wider determinant of health. Private Rented Sector (PRS) housing is generally the worst quality of housing stock across tenures.
Rachael McClatchey, Claire F. Ferraro, Ellis Turner, Jennifer Harris, Jonathan Banks   +4 more
doaj   +1 more source

Response Analysis of a Ballasted Rail Track Constructed on Soft Soil by 3D Modeling

Advances in Civil Engineering, 2023
The displacement, stress, and strain distributions of railway embankments on the soft deltaic deposit of the Ganges–Brahmaputra floodplain are investigated.
Iram Lamiya Hoque, Shamontee Aziz, Joya Rani Mallick, Md. Arifuzzaman Nayeem, Tamanna-E-Hafiz Maisha, F. M. Zahid Hossain, A. F. M. S. Amin   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Research of Small Caliber Steel Pipe Piles to Reinforce the Foundation of Check Dam and Preventit from Scouring by Debris Flow

工程科学与技术, 2019
Scouring below the check dam is a doomed consequence after the upstream reservoir is fully deposited by debris. With the boulders crashing and debris flow scouring, apron, auxiliary dam or submerged dike which is commonly used as an erosion-control below
Shengwei SHI, Jiankang LIU, Qiang CAI, Luxu ZHOU   +3 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Following the Crowd: Unveiling the Impact of Macroeconomic Shocks and Monetary Policy Shifts on Herding Dynamics in the Bangladesh Equity Market

Economies
The study examines the dynamics of herding behavior in relation to macroeconomic shocks and monetary policy shifts in the Bangladesh equity market. By employing robust empirical methodologies across distinct market states including bullish, bearish ...
Muhammad Enamul Haque, Mahmood Osman Imam   +1 more
doaj   +1 more source

OPTIMISATION OF KAOLIN DEPOSIT MODELING USING GEOSTATISTICAL METHODS OF SPATIAL INTERPOLATION [PDF]

Sustainable Extraction and Processing of Raw Materials Journal
. The paper presents a comprehensive approach to optimising kaolin deposit modelling using geostatistical methods of spatial interpolation. The study focuses on improving the assessment of the spatial distribution of mineral components using the example
Ihor Piskun, Lesia Sitsinska, Roman Ihnatiuk   +2 more
doaj   +1 more source