Results 31 to 40 of about 67,235 (266)

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Cooperative exploration model of coal–Ge deposit: A case study of the Wulantuga coal–Ge deposit in Shengli coalfield, Inner Mongolia, China

Energy Exploration & Exploitation
Germanium (Ge) is an excellent organophilic and dispersed semiconductor resource, which is irreplaceable in emerging industries such as new materials, new energy, aerospace, industrial smelting, national defense, military industry, and modern information
Xin Li, Yingchun Wei, Daiyong Cao, Laixin Xu, Yun Zhang, Jinhao Wei, Bo Dong   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Response Analysis of a Ballasted Rail Track Constructed on Soft Soil by 3D Modeling

Advances in Civil Engineering, 2023
The displacement, stress, and strain distributions of railway embankments on the soft deltaic deposit of the Ganges–Brahmaputra floodplain are investigated.
Iram Lamiya Hoque, Shamontee Aziz, Joya Rani Mallick, Md. Arifuzzaman Nayeem, Tamanna-E-Hafiz Maisha, F. M. Zahid Hossain, A. F. M. S. Amin   +6 more
doaj   +1 more source

Geotechnological Foundations of Mining Natural-Technogenic Deposits in Donbas

Journal of Geology, Geography and Geoecology, 2020
The purpose of this study is to substantiate theoretically and technologically both parameters, formation and recovery schemes to use natural-technogenic and capacity resources of the mined coal deposits with the help of a set of geo-modules providing their activation, extraction, and storage depending on seasonable irregularity of energy consumption ...
Nataliia I. Dereviahina, Anatolii S. Kobets, Olexander V. Inkin   +2 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Numerical modeling of connected piled raft foundation under seismic loading in layered soils

Journal of the Mechanical Behavior of Materials, 2023
Until recently, the behavior of connected piled raft foundation was not fully understood in the seismically active region due to the complex dynamic soil–pile–foundation structure interaction.
Ali Ahmed M., Karkush Mahdi O., Al-Jorany Ala N.   +2 more
doaj   +1 more source

Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes

EBioMedicine, 2022
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by the formation of Lewy bodies comprised mainly of α-synuclein.
Yihang Han, Di Wu, Yanjuan Wang, Jian Xie, Zhijun Zhang   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source