Results 261 to 270 of about 8,780,344 (351)

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Reply to: Methodological Issues in Taquet et al.'s analysis preclude any conclusions regarding AS01 adjuvant's specific role in dementia prevention. [PDF]

NPJ Vaccines
Taquet M, Todd JA, Harrison PJ.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Exploring adaptive health technology assessment for evaluating 10 cancer interventions: insights and lessons from a pilot study in India. [PDF]

BMJ Evid Based Med
Ghosh S, Pramesh CS, Sengar M, Ranganathan P, Ruiz F, Wadasadawala T, Nayak P, Thorat J, Ashok A, Singh M, Mehndiratta A, Nemzoff C, Shah HA.   +12 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Lifestyle psychiatry: a conceptual framework for application in mental healthcare and support. [PDF]

BMJ Ment Health
Deenik J, Vermeulen JM, Teasdale SB, Schuch FB, Marx W, Perry B, Diez GG, Castellanos N, Elshazly M, Gatera G, Waugh M, Hepsomali P, Bueno-Antequera J, Borrueco Sánchez J, Lopez Moral A, López-Sánchez C, Oviedo Caro MA, Dejonge M, Noortman C, van Schothorst M, den Bleijker N, Scrivano L, Noordsy DL, Fabian H, Jachyra P, Chapman J, Merlo G, Manger S, O'Neil A, Machaczek KK, Ardill-Young O, Ramírez P, Matthews E, Lambert J, Firth J, Hassan L, Jacka FN, Ward P, Stubbs B, Cahn W, Rosenbaum S, Vancampfort D, Firth J.   +42 more
europepmc   +1 more source

Computer Printouts as Evidence: Stricter Foundation or Presumption of Reliability?

, 1992
Mark A. Johnson
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Virtual Reality Simulation for Orthopedic Surgical Training: A Narrative Review of Current Evidence and Educational Impact. [PDF]

Cureus
Soffar A, Elkohail A, Elbanna M, Kassem HA, Murhekar S, Millat MS, Sayed A, Shehata R, Ali Hamoud M, Khalil N.   +9 more
europepmc   +1 more source