Results 271 to 280 of about 8,424,075 (351)

Crosstalk in Multidisciplinary Approaches for Evidence-Based Medicine. [PDF]

J Multidiscip Healthc
Wang YC, Kumar S, Kung WM.
europepmc   +1 more source

The value of theory- and evidence-based intellectual dialogue on foundational elements of the IB field [PDF]

Alain Verbeke
openalex   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

Framework to guide the use of mathematical modelling in evidence-based policy decision-making. [PDF]

BMJ Open
Oliwa J, Guleid FH, Owek CJ, Maluni J, Jepkosgei J, Nzinga J, Were VO, Sim SY, Walekhwa AW, Clapham H, Dabak S, Kc S, Hadley L, Undurraga E, Hagedorn BL, Hutubessy RC.   +15 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Immune-related gene expression with colorectal cancer risk: a Mendelian randomization analysis. [PDF]

Discov Oncol
Tan X, He W, Chen T, Yang W, Huang D, Zhang H, Luo Y, Lu M, Zhang Z, Ji J, Liu H.   +10 more
europepmc   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

British Elbow and Shoulder Society patient care pathway: Frozen shoulder. [PDF]

Shoulder Elbow
Rupani N, Gwilym SE, BESS Frozen Shoulder Working Group.   +2 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Systematic screening for atrial fibrillation with non-invasive devices: a systematic review and meta-analysis. [PDF]

Lancet Reg Health Eur
Wahab A, Nadarajah R, Larvin H, Farooq M, Raveendra K, Haris M, Nadeem U, Joseph T, Bhatty A, Wilkinson C, Khunti K, Vedanthan R, Camm AJ, Svennberg E, Lip GY, Freedman B, Wu J, Gale CP.   +17 more
europepmc   +1 more source