Results 61 to 70 of about 1,900,275 (265)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Models of Palliative Care Delivery for Individuals with Cystic Fibrosis: Cystic Fibrosis Foundation Evidence-Informed Consensus Guidelines. [PDF]

J Palliat Med, 2021
Kavalieratos D, Georgiopoulos AM, Dhingra L, Basile MJ, Rabinowitz E, Hempstead SE, Faro A, Dellon EP.   +7 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Research evidence communication for policy-makers: a rapid scoping review on frameworks, guidance and tools, and barriers and facilitators

Health Research Policy and Systems
Background Communication is a multifaceted process, ranging from linear, one-way approaches, such as transmitting a simple message, to continuous exchanges and feedback loops among stakeholders.
Jorge Otávio Maia Barreto, Roberta Crevelário de Melo, Letícia Aparecida Lopes Bezerra da Silva, Bruna Carolina de Araújo, Cintia de Freitas Oliveira, Tereza Setsuko Toma, Maritsa Carla de Bortoli, Peter Nichols Demaio, Tanja Kuchenmüller   +8 more
doaj   +1 more source

Social support interventions for life satisfaction of older adults in long-term care: A systematic review and meta-analysis

Aging and Health Research
Background: Older adults residing in long-term care homes often experience isolation, resulting in increased feelings of vulnerability, reduced quality of life, and poorer health outcomes.
Tiffany Yu, Alex Sy, Angela Wang, Mihir Kamra, Philip Yu, Tejanth Pasumarthi, Neha Tangri, Rebecca L. Morgan   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Application of artificial intelligence to measure and predict patient values and preferences: a scoping review

npj Digital Medicine
Patients’ voices are often difficult to capture directly in healthcare decisions. This scoping review examines how artificial intelligence (AI) has been applied to measure and predict patient values and preferences, aiming to evaluate its potential to ...
Mengting Yang, Yuan Luo, Tong He, Sha Diao, Hailong Li, Kun Zou, Glen Stewart Hazlewood, Per Olav Vandvik, Leticia Kawano-Dourado, Daniel de Araujo Dourado, Krista Dagsvik, Xiaoxi Zeng, Wei Zhang, Lingli Zhang, Linan Zeng   +14 more
doaj   +1 more source

Multicomponent hospital-led interventions to reduce hospital stay for older adults following elective surgery: a systematic review

Health Services and Delivery Research, 2019
Background: Elective older adult inpatient admissions are increasingly common. Older adults are at an elevated risk of adverse events in hospital, potentially increasing with lengthier hospital stay.
Michael Nunns, Liz Shaw, Simon Briscoe, Jo Thompson Coon, Anthony Hemsley, John S McGrath, Christopher J Lovegrove, David Thomas, Rob Anderson   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Atomic Evidence: The Foundations of Structural Molecular Biology

Science Progress, 2011
Atomic structures of biomolecules have provided the experimental evidence for many of the major discoveries in molecular biology, including the basic principles of protein folding and function, modes of biological information and energy flow, and mechanisms of molecular evolution.
openaire   +2 more sources