Results 71 to 80 of about 8,780,344 (351)

Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation.

American Journal of Kidney Diseases, 2018
Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome, but its relationship to kidney disease, cardiovascular disease, and diabetes remains controversial.
Richard J. Johnson, G. Bakris, C. Borghi, M. Chonchol, D. Feldman, M. Lanaspa, T. Merriman, O. Moe, D. Mount, L. G. Sánchez Lozada, E. Stahl, D. Weiner, G. Chertow   +12 more
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis

BMJ Open, 2019
Objective Evaluate effectiveness, harms and burdens of faecal blood testing, sigmoidoscopy and colonoscopy screening for colorectal cancer over 15 years.Design We performed an update of a Cochrane systematic review, and performed network meta-analysis ...
Per Olav Vandvik, Lyubov Lytvyn, Joseph C Anderson, Lise M Helsingen, Henriette C Jodal, Louise Emilsson   +5 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Efficacy, safety, and immunogenicity of biosimilars compared with the biologic etanercept in patients with rheumatoid arthritis: a systematic review and meta-analysis

Systematic Reviews
Background Biosimilar etanercept presents itself as an innovative therapeutic opportunity for inflammatory and autoimmune diseases, however, its efficacy, safety, and immunogenicity in relation to the reference biological agent for the treatment of ...
Aurélio Matos Andrade, Juliana da Motta Girardi, Erica Tatiane da Silva, Jakeline Ribeiro Barbosa, Daniella Cristina Rodrigues Pereira   +4 more
doaj   +1 more source

Ultrasound-Based Scoring System for Indication of Pyeloplasty in Patients With UPJO-Like Hydronephrosis

Frontiers in Pediatrics, 2020
Background: Previous scoring systems have used renal scan parameters to assess severity of ureteropelvic junction obstruction-like hydronephrosis (UPJO-like HN), however this information is not always reliable due to protocol variation across centers and
Bruce Li, Melissa McGrath, Melissa McGrath, Melissa McGrath, Forough Farrokhyar, Forough Farrokhyar, Luis H. Braga, Luis H. Braga, Luis H. Braga, Luis H. Braga   +9 more
doaj   +1 more source

2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis

Arthritis care & research, 2018
Objective: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF ...
Jasvinder A. Singh, G. Guyatt, A. Ogdie, Dafna D. Gladman, C. Deal, A. Deodhar, M. Dubreuil, J. Dunham, M. E. Husni, Sarah Kenny, J. Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, J. F. Merola, Julie Miner, Christopher T. Ritchlin, B. Siaton, Benjamin J. Smith, A. V. Van Voorhees, A. Jonsson, A. A. Shah, Nancy M. Sullivan, Marat Turgunbaev, Laura C Coates, A. Gottlieb, M. Magrey, W. B. Nowell, A. Orbai, Soumya Reddy, J. Scher, E. Siegel, M. Siegel, Jessica A Walsh, Amy S. Turner, J. Reston   +35 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Acupuncture techniques for COPD: a systematic review

BMC Complementary Medicine and Therapies, 2020
Background This is the second part of a large spectrum systematic review which aims to identify and assess the evidence for the efficacy of non-pharmacological acupuncture techniques in the treatment of chronic obstructive pulmonary disease (COPD).
Carles Fernández-Jané, Jordi Vilaró, Yutong Fei, Congcong Wang, Jianping Liu, Na Huang, Ruyu Xia, Xia Tian, Ruixue Hu, Lingzi Wen, Mingkun Yu, Natàlia Gómara-Toldrà, Mireia Solà-Madurell, Mercè Sitjà-Rabert   +13 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source