Results 31 to 40 of about 26,042 (268)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Settlement of Rectangular Foundations On Overconsolidated Clays

open access: yesSoils and Foundations, 1975
The immediate and consolidation settlements of a uniformly loaded rectangular area on a overconsolidated clay which is cross anisotropic with respect to its elastic properties are obtained. Tables and graphs are presented for practical use.
NAYAK, M., CHAKRABARTI, U.K.
openaire   +2 more sources

Superimposed stress method to calculate settlement of embankment with rigid-pile composite foundation

open access: yesYantu gongcheng xuebao, 2018
An important cause for the practical settlement of some embankments with rigid-pile composite foundation larger than calculated settlement is the severe serious defects of the existing methods for settlement calculation. The superimposed stress method is
LIU Ji-fu 1, ZHENG Gang 2, GONG Xiao-nan 3
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Shield Cutting Pile-Group Implementation Effects on the Superstructure

open access: yesAdvances in Civil Engineering, 2022
The shield tunneling method is widely used in urban subway construction. However, as the layer stress state changes during shield tunnel construction, layer displacement and surface deformation occur accordingly.
Chi Zhang   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Application of the Richards Model in Settlement Prediction of Loess-Filled Foundations

open access: yesApplied Sciences, 2022
The Richards equation has high plasticity and compatibility. Compared with other curve equations, it has higher applicability and accuracy in describing S-shaped curves.
Yong Yang   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Surcharge Load Effect on Additional Ground Settlement of Narrow and Elongated Foundation Pit

open access: yesChengshi guidao jiaotong yanjiu
ObjectiveIn foundation pit engineering, surcharge load acting on the perimeter of the foundation pit (hereinafter referred to as "pit perimeter") will induce additional ground settlement, which exerts a significant impact on the safety of the foundation ...
Ningjie HU, Nianwu LIU, Kai FANG
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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