Results 101 to 110 of about 6,951,627 (287)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Monitoring program design for data‐limited marine biogenic habitats: A structured approach

Ecology and Evolution, 2019
Marine biogenic habitats—habitats created by living organisms—provide essential ecosystem functions and services, such as physical structuring, nutrient cycling, biodiversity support, and increases in primary, secondary, and tertiary production. With the
Tse‐Lynn Loh, Stephanie K. Archer, Anya Dunham   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Location and natural history are key to determining impact of the 2021 atmospheric heatwave on Pacific Northwest rocky intertidal communities

Frontiers in Marine Science
IntroductionIn late June 2021, the Pacific Northwest region of the United States and Canada experienced an unprecedented atmospheric heatwave that co-occurred with one of the lowest day-time tide series of the year.
C. Melissa Miner, Helen D. Berry, Heath Bohlmann, Megan N. Dethier, Steven C. Fradkin, Rani Gaddam, Wendel W. Raymond, Peter T. Raimondi   +7 more
doaj   +1 more source

The resilience of reef invertebrate biodiversity to coral mortality

Ecosphere, 2016
Foundation species provide many important ecosystem functions including the provision of habitat for diverse communities, but their degradation and mortality has the potential to compromise these roles.
Hannah R. Nelson, Caitlin D. Kuempel, Andrew H. Altieri   +2 more
doaj   +1 more source

Intraspecific variation in a predator changes intertidal community through effects on a foundation species. [PDF]

Ecol Evol, 2023
Contolini GM, Palkovacs EP.
europepmc   +1 more source

Irish Hospice Foundation Annual Report 2023

The Time to Reflect survey was commissioned by Irish Hospice Foundation to explore the impact of COVID-19 on the experiences and perceptions of the Irish population in relation to dying, death, and bereavement during this time.
Irish Hospice Foundation
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