Results 111 to 120 of about 6,992,561 (287)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Ecosphere, 2018 Understanding the role of interactions in influencing community structure and ecosystem function is a goal in ecology, and identifying biotic entities that are strong interactors is imperative for setting targeted conservation strategies.
Sebastian A. Heilpern +1 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Summer Foundation annual report 2015/2016
, 2016 Summer Foundation annual report for the 2015-2016 financial year. Established in 2006, the key aim of the Summer Foundation is to change human service policy and practice related to young people in nursing homes.
Summer Foundation
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Wave stress and biotic facilitation drive community composition in a marginal hard‐bottom ecosystem
Ecosphere, 2019 Ecological patterns are inherently scale‐dependent and driven by the interplay of abiotic gradients and biotic processes. Despite the fundamental importance of such gradients, there are many gaps in our understanding of how abiotic stress gradients ...
Mats Westerbom +5 more
doaj +1 more source
Intraspecific variation in a predator changes intertidal community through effects on a foundation species. [PDF]
Ecol Evol, 2023 Contolini GM, Palkovacs EP.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Irish Hospice Foundation Annual Report 2023
The Time to Reflect survey was commissioned by Irish Hospice Foundation to explore the impact of COVID-19 on the experiences and perceptions of the Irish population in relation to dying, death, and bereavement during this time.
Irish Hospice Foundation
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