Results 161 to 170 of about 915,687 (355)
Epimorphisms and acyclic types in univalent foundations
We characterize the epimorphisms in homotopy type theory (HoTT) as the fiberwise acyclic maps and develop a type-theoretic treatment of acyclic maps and types in the context of synthetic homotopy theory as developed in univalent foundations.
Buchholtz, Ulrik +2 more
core +1 more source
The Philosophical Foundations of Human Rights: An Overview [PDF]
, 2015 A survey essay on the philosophical foundations of human rights, introducing our 38-essay edited ...
Liao, S Matthew +2 more
core
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
, 1995 We review the book Foundations of Artificial Intelligence (ed. David Kirsch, MIT Press, Cambridge, MA, 1993) and present a framework for the analysis of theories of artificial intelligence.
Eric K. Jones +2 more
core
Local Leadership, Global Impact: Community Foundations and the Sustainable Development Goals [PDF]
, 2018 Local Leadership, Global Impact: Community Foundations and the Sustainable Development Goals highlights the growing presence and impact of community foundations around the world and teaches community foundations how to apply the lens of the sustainable ...
Natalie Ross
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Sweden: Exploratory overview of research foundations [Elektronisk resurs]
, 2009 Sweden has a long and rich foundation history. In the early 21st century, there are currently some 14,500 larger foundations – foundations that have more than 350,000 Swedish krona (SEK) (about €34,250) in capital and thus are obliged to register with ...
Einarsson, Stefan,
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source