Results 31 to 40 of about 173,621,605 (261)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
Logic, Geometry And Probability Theory [PDF]
, 2013 We discuss the relationship between logic, geometry and probability theory under the light of a novel approach to quantum probabilities which generalizes the method developed by R. T.
Federico Holik, Holik, Federico
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BuildingsComposite pile foundation, as a new structural form in foundation engineering, has been widely used in the field of bridge engineering due to its overall superiority.
Yi Wang, Guoyun Lu, Fenghui Dong
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Quantum Probability and Decision Theory, Revisited [PDF]
, 2002 An extended analysis is given of the program, originally suggested by Deutsch, of solving the probability problem in the Everett interpretation by means of decision theory.
Wallace, David
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Revisiting Probabilistic Metric Spaces
International Journal of TopologyThe field of probabilistic metric spaces has an intrinsic interest based on a blend of ideas drawn from metric space theory and probability theory. The goal of the present paper is to introduce and study new ideas in this field.
Michael D. Rice
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Fragile systems: A hidden-variable Bayesian framework leading to quantum theory
Results in PhysicsAn understanding of quantum theory in terms of new, underlying descriptions capable of explaining the existence of non-classical correlations, non-commutativity of measurements and other unique and counter-intuitive phenomena remains still a challenge at
Yasmín Navarrete, Sergio Davis
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source