Results 91 to 100 of about 724,876 (319)

The Engineering Design and Prototyping of an Auxiliary Standing Toilet Chair Driven by Electric Cylinders

open access: yesMachines
As physical capabilities decline with age, elderly individuals often require assistance from others when using the toilet. An auxiliary standing toilet chair can enhance convenience for the elderly, allowing them to use the toilet independently ...
Long-Chang Hsieh   +3 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

RESEARCH OF THE MOBILE TOWER CRANE TOWER DOWN FOUR-BAR LINKAGE

open access: yesJixie qiangdu, 2016
To solve the problem of transition of the tower crane with high center of gravity,through sex difference,fixed transportation for the tower body and its attached parts being put down may be regarded as a fast and efficient method.
SHANGGUAN JianLin, LIU DePing
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Broad modulus range nanomechanical mapping by magnetic-drive soft probes

open access: yesNature Communications, 2017
Force-distance curve-based atomic force microscopy can measure material nanomechanics, but only if the probe and material stiffness match, which limits the measurement range.
Xianghe Meng   +5 more
doaj   +1 more source

Force and Slip Displacement of Fibre Cemboard Panels Subjected To Four-Point Bending Test

open access: diamond, 2022
Nur Amirah Najwa Mohammed   +7 more
openalex   +2 more sources

Acoustic Radiation Force: A Review of Four Mechanisms for Biomedical Applications [PDF]

open access: hybrid, 2021
Armen Sarvazyan   +2 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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