Results 101 to 110 of about 9,873,801 (377)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Integration of a new position sensor based on four quadrant fiber optic bundle to measure the cantilever deflections in atomic force microscopy head [PDF]

, 2015
Younes Boukellal, Sebastien Ducourtieux
openalex   +2 more sources

The Engineering Design and Prototyping of an Auxiliary Standing Toilet Chair Driven by Electric Cylinders

Machines
As physical capabilities decline with age, elderly individuals often require assistance from others when using the toilet. An auxiliary standing toilet chair can enhance convenience for the elderly, allowing them to use the toilet independently ...
Long-Chang Hsieh, Tzu-Hsia Chen, Po-Cheng Lai, Tsung-Ming Huang   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

RESEARCH OF THE MOBILE TOWER CRANE TOWER DOWN FOUR-BAR LINKAGE

Jixie qiangdu, 2016
To solve the problem of transition of the tower crane with high center of gravity,through sex difference,fixed transportation for the tower body and its attached parts being put down may be regarded as a fast and efficient method.
SHANGGUAN JianLin, LIU DePing
doaj  

Modeling DNA Flexibility: Comparison of Force Fields from Atomistic to Multiscale Levels.

Journal of Physical Chemistry B, 2019
Accurate parameterization of force fields (FF) is of ultimate importance for computer simulations to be reliable and to possess a predictive power.
Vishal Minhas, Tiedong Sun, A. Mirzoev, N. Korolev, A. Lyubartsev, L. Nordenskiöld   +5 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Broad modulus range nanomechanical mapping by magnetic-drive soft probes

Nature Communications, 2017
Force-distance curve-based atomic force microscopy can measure material nanomechanics, but only if the probe and material stiffness match, which limits the measurement range.
Xianghe Meng, Hao Zhang, Jianmin Song, Xinjian Fan, Lining Sun, Hui Xie   +5 more
doaj   +1 more source