Results 121 to 130 of about 9,873,801 (377)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Design of Compliant Constant-force Mechanism based on Additional Spring Double-slider Four-bar Mechanism

open access: yesJixie chuandong, 2020
A design method of compliant gripper based on pseudo rigid body model is presented.A compliant clamping mechanism with constant force characteristics is constructed based on the additional spring double-slide four-bar mechanism.The mechanism position ...
Zhang Kai   +3 more
doaj  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

THIN-WALLED FOUR-POINT CONTACT BALL BEARING CONTACT FINITE ELEMENT ANALYSIS

open access: yesJixie qiangdu, 2018
Based on the ANSYS finite element software,the method of dividing the contact area of the four point contact ball bearing is proposed. Establish a uniform thin four point contact ball bearing 1/2 single rolling and ring and the bearing finite element ...
WU Li   +3 more
doaj  

Research on dimension coupling of piezoelectric three-component force unit based on sensor assembly error

open access: yesAdvances in Mechanical Engineering, 2019
In the process of manufacturing and operation of mechanical equipment, accurate measurement of vector force provides an important basis for real-time control of working conditions and process adjustment to ensure the performance.
Jun Zhang   +5 more
doaj   +1 more source

The Electromagnetic Unification of Four Forces and Electromagnetic Structures of Particles

open access: yesOALib, 2018
Recently, the book “Electromagnetic Unification of Four Forces” (ISBN978-3-659-76798-2) was published, compiling the progressions in physics made by the world people, manifested in television while led notably by me and the Members in the world satellite networks from India, Zhejiang and USA.
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Force-Symmetric Type Two-Channel Bilateral Control System Based on Higher-Order Disturbance Observer

open access: yesIEEE Access
In a bilateral control system, reducing the information-transmission channel between the master and slave systems has advantages, such as suppressing data traffic, reducing stored data, and simplifying the control-system design. The position/force hybrid-
Yuki Nagatsu
doaj   +1 more source

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