Results 191 to 200 of about 83,323 (251)

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Integrated life cycle assessment and multicriteria decision making framework for evaluating renewable energy technologies at Istanbul Airport. [PDF]

Sci Rep
Zenginoğlu A, Yüksel FŞ.
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

The bactericidal efficacy of two antiseptics against common pathogens associated with catheter-associated urinary tract infection in the elderly under divergent conditions: A laboratory-based study. [PDF]

BMC Infect Dis
Shen L, Sun W, Zhou K, Zhang Y, Lei Y, Ni C.   +5 more
europepmc   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Ex vivo study of Porcine esophagus magnetic resonance imaging with a compact endoluminal coil. [PDF]

Sci Rep
Zhang S, Pan H, Teng Y, Li G, Zhu H, Li Y, Li R.   +6 more
europepmc   +1 more source

Firms and public service provision in Russia [PDF]

, 2003
Haaparanta, Pertti, Juurikkala, Tuuli et al   +1 more
core  

Designing Scalable Mechano‐Virucidal Nanostructured Acrylic Surfaces for Enhanced Viral Inactivation

Advanced Science, EarlyView.
Can a surface be designed to physically break viruses? This study explores how nanoscale geometry—specifically the spacing of tiny pillars—can determine whether viruses remain intact or rupture. Using flexible acrylic and a scalable fabrication process, the authors develop nanopillared, transparent surfaces that show strong antiviral activity without ...
Samson W. L. Mah, Denver P. Linklater, Vassil Tzanov, Chaitali Dekiwadia, Sergey Rubanov, Phuc H. Le, Laleh Tafakori, Ranya Simons, Graeme Moad, Soichiro Saita, Takashi Yanagishita, Hideki Masuda, Vladimir Baulin, Natalie A. Borg, Elena P. Ivanova   +14 more
wiley   +1 more source

New York State Climate Impacts Assessment Chapter 06: Energy. [PDF]

Ann N Y Acad Sci
Meier S, Marcotullio PJ, Carney P, DesRoches S, Freedman J, Golan M, Gundlach J, Parisian J, Sheehan P, Slade WV, Teron L, Wei K, Stevens A.   +12 more
europepmc   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source