Results 111 to 120 of about 7,684 (200)

Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms [PDF]

, 2017
Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2–5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between ...
Cheng, Liang, Lyu, Bingjian, Roth, Lawrence M.   +2 more
core   +1 more source

An epigenomic threshold hypothesis for integrating dynamic environmental signals into functional models of developmental polyphenisms

Functional Ecology, Volume 39, Issue 11, Page 3050-3060, November 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley   +1 more source

Differential Apoptotic and Proliferative Activities of Wild-type FOXL2 and Blepharophimosis-ptosis-epicanthus Inversus Syndrome (BPES)-associated Mutant FOXL2 Proteins

Journal of Reproduction and Development, 2014
FOXL2 is an essential transcription factor that is required for proper development of the ovary and eyelid. Mutations in FOXL2 cause an autosomal dominant genetic disorder, blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). BPES type I patients have eyelid malformation and premature ovarian failure leading to infertility, whereas women with ...
KIM, Jae-Hong, BAE, Jeehyeon
openaire   +3 more sources

Chitosan-encapsulated linoleic acid from Leucaena leucocephala (Lam.) de Wit. inhibits FOXL2 mutation in MNU-induced ovarian granulosa cell tumors in Wistar rats

Next Nanotechnology
One of the biggest challenges in drug delivery is delivering drugs to their sites of action to avoid the systemic side effects that are common with most antineoplastic drugs.
Cletus Anes Ukwubile, Hassan Braimah Yesufu, Roland Nnaemeka Okoro, Ahamefula Anslem Ahuchaogu, Blessing Ogechukwu Umeokoli, Matthew Onyema Agu, Nnamdi David Menkiti, Patrick Akoji Ida   +7 more
doaj   +1 more source

Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells [PDF]

, 2017
Objective. Resistance to standard chemotherapy poses a major clinical problem in the treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique ovarian cancer subtype for which efficient treatment options are lacking in ...
Aittokallio, Tero, Andersson, Noora, Anttonen, Mikko, Butzow, Ralf, Farkkila, Anniina, Haltia, Ulla-Maija, Heikinheimo, Markku, Kallioniemi, Olli, Kankainen, Matti, Kulesskiy, Evgeny, Leminen, Arto, Riska, Annika, Tang, Jing, Unkila-Kallio, Leila, Wennerberg, Krister, Yadav, Bhagwan   +15 more
core   +1 more source

Assessment and classification of sex cord‐stromal tumours of the testis: recommendations from the testicular sex cord‐stromal tumour (TESST) group, an Expert Panel of the Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP)

Histopathology, Volume 87, Issue 5, Page 660-676, November 2025.
FH immunohistochemistry is recommended in clinically malignant Leydig cell tumours and in primary Leydig cell tumours with aggressive histopathologic features. Aims Testicular sex cord‐stromal tumours (TSCSTs) are relatively rare, accounting for ~5% of all testicular neoplasms.
Andres M Acosta, Maurizio Colecchia, Eva Comperat, Kristine M Cornejo, Anthony J Gill, Sounak Gupta, John C Cheville, Muhammad T Idrees, Chia‐Sui Kao, Fiona Maclean, Andres Matoso, Maria Rosaria Raspollini, Kvetoslava Michalova, Miguel Reyes Múgica, Satish K Tickoo, Toyonori Tsuzuki, Thomas M Ulbright, Sean R Williamson, Stephanie Siegmund, Lynette M Sholl, Pilar Gonzalez‐Peramato, Daniel M Berney   +21 more
wiley   +1 more source

Novel action of FOXL2 as mediator of Col1a2 gene autoregulation

Developmental Biology, 2016
FOXL2 belongs to the evolutionarily conserved forkhead box (FOX) superfamily and is a master transcription factor in a spectrum of developmental pathways, including ovarian and eyelid development and bone, cartilage and uterine maturation. To analyse its action, we searched for proteins that interact with FOXL2.
Marongiu Mara, Deiana Manila, Marcia Loredana, Sbardellati Andrea, Asunis Isadora, Meloni Alessandra, Angius Andrea, Cusano Roberto, Loi Angela, Crobu Francesca, Fotia Giorgio, Cucca Francesco, Schlessinger David, Crisponi Laura   +13 more
openaire   +3 more sources

Gonadal transcriptome sequencing reveals sexual dimorphism in expression profiling of sex-related genes in Asian arowana (Scleropages formosus)

Frontiers in Genetics
Asia arowana (Scleropages formosus) is an ornamental fish with high economic value, while its sex determination mechanism is still poorly understood. By far, no morphological evidence or molecular marker has been developed for effective distinguishment ...
Chenxi Zhao, Chenxi Zhao, Chao Bian, Chao Bian, Xidong Mu, Xinhui Zhang, Xinhui Zhang, Qiong Shi, Qiong Shi, Qiong Shi   +9 more
doaj   +1 more source

Cloning, identification, and functional analysis of foxl2 gene and its expression after 17β‐estradiol (E2) treatment in Dabry’s sturgeon, Acipenser dabryanus

Frontiers in Marine Science
The study focuses on the critically endangered Dabry’s sturgeon (Acipenser dabryanus), a species on the brink of extinction in the wild. This research investigates the role of the Forkhead box protein L2 (foxl2) in the gonadal development and ...
Yacheng Hu, Yacheng Hu, Ruihua Tan, Tingting Shu, Tingting Shu, Zhong Chu, Haoran Wang, Yining Chen, Xin Zhu, Xin Zhu, Yang Li, Yang Li, Binzhong Wang, Binzhong Wang, Baifu Guo, Baifu Guo, Runqiu Wang, Runqiu Wang, Huantao Qu, Huantao Qu, Dezhi Zhang, Dezhi Zhang, Hejun Du, Hejun Du, Zhiyuan Li, Zhiyuan Li, Dan Xu, Wei Jiang, Wei Jiang, Qingfei Li, Yuanjin Yang, Yuanjin Yang   +31 more
doaj   +1 more source

Molecular cloning, expression and functional analysis of foxl2 from Chinese sturgeon (Acipenser sinensis) in relation to sex differentiation

Frontiers in Marine Science
IntroductionOur understanding of the regulatory mechanisms that govern the development of sexual characteristics in sturgeon, particularly the Chinese sturgeon (Acipenser sinensis), is limited.
Yacheng Hu, Yacheng Hu, Ruihua Tan, Yang Li, Yang Li, Tingting Shu, Tingting Shu, Gang Yang, Zhong Chu, Haoran Wang, Xueqing Liu, Xueqing Liu, Xin Zhu, Xin Zhu, Binzhong Wang, Binzhong Wang, Baifu Guo, Baifu Guo, Runqiu Wang, Runqiu Wang, Huantao Qu, Huantao Qu, Haoyong Song, Haoyong Song, Dezhi Zhang, Dezhi Zhang, Hejun Du, Hejun Du, Zhiyuan Li, Zhiyuan Li, Jianbo Chang, Jianbo Chang, Dianchang Wang, Dan Xu, Wei Jiang, Wei Jiang, Qingfei Li, Yuanjin Yang, Yuanjin Yang   +38 more
doaj   +1 more source