Results 201 to 210 of about 38,355 (234)
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Targeting FoxO1 for Hypertriglyceridemia
Current Drug Targets, 2011Hypertriglyceridemia is characterized by increased production and decreased clearance of triglyceride-rich lipoproteins including very low-density lipoprotein (VLDL) and chylomicron. Due to its proatherogenic profile, hypertriglyceridemia contributes to the development of atherosclerosis and coronary artery disease.
Dae Hyun, Kim +3 more
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miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes
Biochemical and Biophysical Research Communications, 2009FoxO1 is a master regulator of signaling pathways used by growth factors and hormones, including insulin. Its activity is regulated by changes in subcellular localization coupled to post-translational modifications such as phosphorylation, ubiquitination, and acetylation.
Larbi Kamal, Hasseine +5 more
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Journal of Zhejiang University-SCIENCE B, 2023
To explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments.
Chao Chen +5 more
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To explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments.
Chao Chen +5 more
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Foxo1 Corepressor (FCoR) and Foxo1 Regulate a-Cell and ß-Cell Identity
Diabetes, 2018We previously identified a Foxo1 binding protein; Foxo1 CoRepressor (FCoR), in adipocytes. FCoR inhibits Foxo1 activity by enhancing its acetylation. FCoR is expressed in pancreatic α- and β-cells from the embryonic stage. Fcor knockout mice (FcorKO) show impaired glucose tolerance, decreased insulin secretion, increased glucagon secretion and ...
NORIKO KODANI, JUN NAKAE, HIROSHI ITOH
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SIRT1–FOXO1 Signaling in Cancer
Journal of Biochemical and Molecular ToxicologyABSTRACTSirt1 (sirtuin 1) is a member of the sirtuin family of NAD+‐dependent histone deacetylases, which mediates the deacetylation of both histone and nonhistone protein substrates, including enzymes and transcription factors. Through this process, Sirt1 regulates gene transcription and activates various cellular functions.
Altaf A. Abdulkhaliq +9 more
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PAX3‐FOXO1 and FGFR4 in alveolar rhabdomyosarcoma
Molecular Carcinogenesis, 2011AbstractWe and others have identified FGFR4 as a direct transcriptional target of the alveolar rhabdomyosarcoma (ARMS) specific fusion protein, PAX3‐FOXO1. We hypothesized fibroblast growth factor receptor 4 (FGFR4) may act as an effector of PAX3‐FOXO1, contributing to PAX3‐FOXO1 tumorigenic phenotypes.
Amy D, Marshall +2 more
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FOXO1/3: Potential suppressors of fibrosis
Ageing Research Reviews, 2018Fibrosis is a universally age-related disease that involves nearly all organs. It is typically initiated by organic injury and eventually results in organ failure. There are still few effective therapeutic strategy targets for fibrogenesis. Forkhead box proteins O1 and O3 (FOXO1/3) have been shown to have favorable inhibitory effects on fibroblast ...
Zhenlong, Xin +8 more
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Assessing the Activity of Transcription Factor FoxO1
2022The transcription factor FoxO1 (forkhead box O1) regulates genes that are involved in development, metabolism, cellular innovation, longevity, and stress responses. Assessment of FoxO1 activity is therefore critical to understand the regulatory network of this transcription factor.
Limin, Shi, Zhipeng, Tao, Zhiyong, Cheng
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FoxO1 – the key for the pathogenesis and therapy of acne?
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2010SummaryFive main factors play a pivotal role in the pathogenesis of acne: androgen dependence, follicular retention hyperkeratosis, increased sebaceous lipogenesis, increased colonization with P. acnes, and inflammatory events. This paper offers a solution for the pathogenesis of acne and explains all major pathogenic factors at the genomic level by a ...
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