Results 61 to 70 of about 38,355 (234)

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Transcriptional Activation by Pax3‐FOXO1 is influenced by the presence of FOXO1 promoter elements

The FASEB Journal, 2012
The translocation of FOXO1 with either Pax3 or Pax 7 has been implicated in the development of Alveolar Rhabdomyosarcoma (ARMS). These translocations yield chimeric proteins containing amino‐terminal portions of either Pax transcription factor fused to carboxy terminal regions FOXO1.
Kelly E. Johanson, Endia L. Blunt, Chantelle L Collins, Elena Skripnikova   +3 more
openaire   +1 more source

FOXO1 Up-Regulates Human L-selectin Expression through Binding to a Consensus FOXO1 Motif [PDF]

Gene Regulation and Systems Biology, 2012
L-selectin plays important roles in lymphocyte homing and leukocyte rolling. Mounting evidence shows that it is involved in many disease entities including diabetes, ischemia/reperfusion injuries, inflammatory diseases, and tumor metastasis. Regulation of L-selectin at protein level has been well characterized.
Lou, Yuefen, Lu, Xiaojiong, Dang, Xitong
openaire   +2 more sources

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Inhibition of Cyclin-Dependent Kinase Phosphorylation of FOXO1 and Prostate Cancer Cell Growth by a Peptide Derived from FOXO1

Neoplasia: An International Journal for Oncology Research, 2011
Increasing evidence suggests that FOXO1 possesses a tumor suppressor function. Inactivation of FOXO1 has been documented in many types of human cancer, and restoring the activity of FOXO1 holds promise for cancer treatment. In this study, we identified a
Huarui Lu, Ping Liu, Yunqian Pan, Haojie Huang   +3 more
doaj   +1 more source

Down-Regulated FOXO1 in Refractory/Relapse Childhood B-Cell Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2020
Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall prevalence of 4/100,000, accounting for 25–30% of all childhood cancers.
Qingqing Zheng, Chuang Jiang, Haiyan Liu, Wenge Hao, Pengfei Wang, Haiying Huang, Ziping Li, Jiabi Qian, Maoxiang Qian, Hui Zhang   +9 more
doaj   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Deciphering the roles of FOXO1 in human neoplasms [PDF]

International Journal of Cancer, 2018
Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of FOXO1 in neoplasms.
Shuai Jiang, Tian Li, Zhi Yang, Wei Hu, Yang Yang   +4 more
openaire   +2 more sources

The сontribution of FOXO family transcription factor genes (FOXO1, FOXO3) to chronic obstructive pulmonary disease

Вавиловский журнал генетики и селекции
Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system and is the third leading cause of death worldwide. In the framework of the most relevant concepts of COPD pathogenesis, the key focus is on accelerated ...
V. A. Markelov, L. Z. Akhmadishina, T. R. Nasibullin, Y. G. Aznabaeva, O. V. Kochetova, N. N. Khusnutdinova, S. M. Izmailova, N. Sh. Zagidullin, G. F. Korytina   +8 more
doaj   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source