Results 91 to 100 of about 10,658,834 (304)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fractional-Order Modeling and Steady-State Analysis of Single-Phase Quasi-Z-Source Pulse Width Modulation Rectifier

IEEE Access
This paper focuses on the fractional-order modeling and analysis of single-phase quasi-Z-source rectifier (qZSR), aims to extend the single-phase qZSR from integer-order domain to fractional-order domain. Additionally, it has been demonstrated explicitly
Xiaoquan Zhu, Ziwen Chen, Bo Zhang
doaj   +1 more source

Fractional Mass-Spring-Damper System Described by Generalized Fractional Order Derivatives

Fractal and Fractional, 2019
This paper proposes novel analytical solutions of the mass-spring-damper systems described by certain generalized fractional derivatives. The Liouville−Caputo left generalized fractional derivative and the left generalized fractional derivative ...
Ndolane Sene, José Francisco Gómez Aguilar   +1 more
doaj   +1 more source

Fractional Order Tube Model Reference Adaptive Control for a Class of Fractional Order Linear Systems

International Journal of Applied Mathematics and Computer Science, 2020
We introduce a novel fractional order adaptive control design based on the tube model reference adaptive control (TMRAC) scheme for a class of fractional order linear systems. By considering an adaptive state feedback control configuration, the main idea
Balaska Hanane, Ladaci Samir, Djouambi Abdelbaki, Schulte Horst, Bourouba Bachir   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Indirect sliding mode adaptive fractional order nonlinear observer based controller with fractional order single-ended primary inductor converter

International Journal of Electrical Power & Energy Systems
Direct Current to Direct Current (DC/DC) converters like the SEPIC (Single-Ended Primary-Inductor Converter) use both passive and active components to control the system via a duty cycle. The SEPIC converter is non-inverting and can both step up and step
Sena Alemu Wondimu, Desalegn Tsega Dagne, Kinde Anlay Fante   +2 more
doaj   +1 more source

Realization of fractional order controllers [PDF]

Acta Montanistica Slovaca, 2003
An approach to realizations of fractional-order controllers is presented. The suggested approach is based on the use of continued fraction expansions.
O’Leary Paul, Dorcak Lubomir, Chen YangQuan, Vinagre Blas M., Podlubny Igor, Petras Ivo   +5 more
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source